Research Papers

Slump Molding of Microchannel Arrays in Soda-Lime Glass for Bioanalytical Device Development

[+] Author and Article Information
Richard E. Billo

Department of Computer Science
and Engineering,
University of Notre Dame,
Notre Dame, IN 46556
e-mail: rbillo@nd.edu

Paul A. Wilson

208 S. Akard Street, Suite 110,
Dallas, TX 75202
e-mail: paulwilson05@gmail.com

John W. Priest

Department of Industrial and Manufacturing
Systems Engineering,
University of Texas at Arlington,
Arlington, TX 76019
e-mail: jpriest@uta.edu

Mario Romero-Ortega

Department of Bioengineering,
University of Texas at Dallas,
Richardson, TX 75080
e-mail: Mario.Romero-Ortega@utdallas.edu

Shannon R. Brunskill

Brunskill Studios, Inc.,
9661 Lynbrook Drive,
Dallas, TX 75238
e-mail: shannonbrunskill@gmail.com

David Keens

Art and Art History Department,
University of Texas at Arlington,
Arlington, TX 76019
e-mail: david@davidkeens.com

1Corresponding author.

Contributed by the Manufacturing Engineering Division of ASME for publication in the JOURNAL OF MICRO- AND NANO-MANUFACTURING. Manuscript received January 29, 2014; final manuscript received August 28, 2014; published online September 26, 2014. Assoc. Editor: John P. Coulter.

J. Micro Nano-Manuf 2(4), 041006 (Sep 26, 2014) (7 pages) Paper No: JMNM-14-1005; doi: 10.1115/1.4028487 History: Received January 29, 2014; Revised August 28, 2014

A slump molding process was developed to place microchannel geometries in a soda-lime glass substrate for a lab-on-chip bioanalytical device. The process was developed to overcome the biological and chemical reactivity associated with current polymer lab-on-a-chip substrates, and as an alternative to using more expensive glass material. A high speed micro mill and UV laser micromachining center were used to fabricate the negative geometries in the graphite mold material that was used. The slumping process of the soda-lime glass was done using a glass kiln. Microchannel dimensions were in the mesa scale range of 50 μm width × 10 μm depth. The heating schedule for slump molding of the soda-lime glass to take its final shape to these dimensions was determined and documented. The functionality of the slumping process and resultant soda-lime glass device was validated through murine nerve tissue experiments conducted through the bioanalytical device that was developed. The research represented a novel use of slump molding, a process traditionally known for producing artistic works for: (a) embossing engineered microchannels and (b) reliably processing a soda-lime glass substrate, a material known to be difficult to work with due to its poor physical properties.

Copyright © 2014 by ASME
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Rodriguez, I., Spicar-Mihalic, S., Kuyper, C. L., Fiorini, G. S., and Chiu, D. T., 2003, “Rapid Prototyping of Glass Microchannels,” Anal. Chim. Acta, 469(1–2), pp. 205–215. [CrossRef]
Sayah, A., Thivolle, P. A., and Prakesh, V. K., 2009, “Fabrication of Microfluidic Mixers With Varying Topography in Glass Using the Powder Blasting Process,” J. Micromech. Microeng., 19(8), p. 085024. [CrossRef]
“Specialty Glass Products, Glass Types and Materials,” http://www.sgpinc.com/materials.htm
Thermo Scientific, “Material Properties Sheet- Microscope Glass Slides,” http://www.thermoscientific.com/en/product/british-standard-microscope-slides.html
“Soda-Lime Glass,” Encyclopædia Britannica Online, http://www.britannica.com/EBchecked/topic/551995/soda-lime-glass
Li, X., Abe, T., and Esashi, M., 2001, “Deep Reactive Ion Etching of Pyrex Glass Using SF6 Plasma,” Sens. Actuators, A, 87(3), pp. 139–145. [CrossRef]
Choi, W., Lee, J., Kim, W. B., Min, B. K., Kang, S., and Lee, S. J., 2004, “Design and Fabrication of Tungsten Carbide Mould With Micropatterns Imprinted by Microlithography,” J. Micromech. Microeng.,” 14(11), pp. 1519–1525. [CrossRef]
Iliescu, C., Jing, J., Tay, F. E. H., Miao, J., and Sun, T., 2005, “Characterization of Masking Layers for Deep Wet Etching of Glass in an Improved HF/HCl Solution,” Surf. Coat. Technol., 198(1–3), pp. 314–318. [CrossRef]
“Glass Fusing Made Easy,” http://www.glass-fusing-made-easy.com
“MatWeb, Your Source for Materials Information,” www.matweb.com
Jacobs, J. A., and Kilduff, T. F., 2004, Engineering Materials Technology: Structures, Processing, Properties, and Selection, 5th ed., Prentice Hall, Upper Saddle River, NJ.
Culler, R., 2010, Glass Art From the Kiln, Schiffer Publishing Ltd., Atglen, PA.
Youn, S. W., Takahashi, M., Goto, H., and Maeda, R., 2007, “Fabrication of Micro-Mold for Glass Embossing Using Focused Ion Beam Femto-Second laser, Eximer Laser and Dicing Techniques,” J. Mater. Process. Technol., 187/188, pp. 326–330. [CrossRef]
Takahashi, M., Sugimoto, K., and Maeda, R., 2005, “Nanoimprint of Glass Materials With Glassy Carbon Molds Fabricated by Focused-Ion-Beam Etching,” Jan. J. Appl. Phys., 44(7B), pp. 5600–5605. [CrossRef]
Hirai, Y., Kanakugi, K., Yamaguchi, T., Yao, K., Kitagawa, S., and Tanaka, Y., 2003, “Fine Pattern Fabrication on Glass Surface by Imprint Lithography,” Microelectron. Eng., 67/68, pp. 237–244. [CrossRef]
Kuhnke, M., Lippert, T., Ortelli, E., Scherer, G. G., and Wokaun, A., 2004, “Microstructuring of Glassy Carbon: Comparison of Laser Machining and Reactive Ion Etching,” Thin Solid Films, 453/454, pp. 36–41. [CrossRef]


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Fig. 1

Lab-on-a-chip microfluidic device design

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Fig. 2

Assembled soda-lime glass device design

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Fig. 3

Slumping process for glass microchannels. (a) Preformed glass slide is placed over the mold, (b) mold and glass are heated in a kiln. As glass melts, it slumps over protrusions in the mold, and (c) resultant glass slide with microchannels.

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Fig. 4

Oxide transferred from a graphite mold to soda-lime glass during a firing. Oxides severely reduce clarity in glass.

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Fig. 5

Outgassing trapped as bubbles resulting from molding soda-lime glass in a vacuum hot press

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Fig. 6

Partially machined graphite mold depicting the large pocket and the unmachined area for microchannels

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Fig. 7

Laser micromachined microchannel protrusions on SFG-2 graphite mold

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Fig. 8

Resultant glass slide with microchannels and wells

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Fig. 9

SEM images of slump molded microchannels in soda-lime glass

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Fig. 10

Wells with connecting microchannels

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Fig. 11

Directed axon growth through microchannels



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