Research Papers

Surface Micropatterning of Pure Titanium for Biomedical Applications Via High Energy Pulse Laser Peening

[+] Author and Article Information
Ninggang Shen, Chelsey N. Pence, Ibrahim T. Ozbolat

Department of Mechanical
and Industrial Engineering,
University of Iowa,
Iowa City, IA 52242

Hongtao Ding

Department of Mechanical
and Industrial Engineering,
University of Iowa,
Iowa City, IA 52242
e-mail: hongtao-ding@uiowa.edu

Robert Bowers, Clark M. Stanford

Dows Institute for Dental Research,
College of Dentistry,
University of Iowa,
Iowa City, IA 52242

Yin Yu

Department of Biomedical Engineering,
University of Iowa,
Iowa City, IA 52242

1Corresponding author.

Contributed by the Manufacturing Engineering Division of ASME for publication in the JOURNAL OF MICRO- AND NANO-MANUFACTURING. Manuscript received June 26, 2014; final manuscript received November 20, 2014; published online December 15, 2014. Assoc. Editor: Nicholas Fang.

J. Micro Nano-Manuf 3(1), 011005 (Mar 01, 2015) (8 pages) Paper No: JMNM-14-1040; doi: 10.1115/1.4029247 History: Received June 26, 2014; Revised November 20, 2014; Online December 15, 2014

Pure titanium is an ideal material for biomedical implant applications for its superior biocompatibility, but it lacks of the mechanical strength required in these applications compared with titanium alloys. This research is concerned with an innovative laser peening-based material process to improve the mechanical strength and cell attachment property of pure titanium in biomedical applications. Evidence has shown that engineered surface with unsmooth topologies will contribute to the osteoblast differentiation in human mesenchymal pre-osteoblastic cells, which is helpful to avoid long-term peri-abutment inflammation issues for the dental implant therapy with transcutaneous devices. However, surface quality is difficult to control or mechanical strength is not enhanced using conventional approaches. In this paper, a novel high energy pulse laser peening (HEPLP) process is proposed to both improve the mechanical strength and introduce a micropattern into the biomedical implant material of a commercially pure Titanium (cpTi). The strong shock wave generated by HEPLP presses a stainless steel grid, used as a stamp, on cpTi foils to imprint a micropattern. To understand the basic science during the process, the HEPLP induced shock wave pressure profile and history are modeled by a multiphysics hydrodynamic numerical analysis. The micropatterns and strength enhancement are then simulated using a dislocation density-based finite element (FE) framework. Finally, cell culture tests are conducted to investigate the biomedical performance of the patterned surface.

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Subramani, K., and Mathew, R. T., 2012, “Chapter 6—Titanium Surface Modification Techniques for Dental Implants—From Microscale to Nanoscale,” Emerging Nanotechnologies in Dentistry, William Andrew Publishing, Boston, MA, pp. 85–102.
Subramani, K., Tran, D., and Nguyen, K. T., 2012, “Chapter 8—Cellular Responses to Nanoscale Surface Modifications of Titanium Implants for Dentistry and Bone Tissue Engineering Applications,” Emerging Nanotechnologies in Dentistry, William Andrew Publishing, Boston, MA, pp. 113–136.
Rack, H. J., and Qazi, J. I., 2006, “Titanium Alloys for Biomedical Applications,” Mater. Sci. Eng. C, 26(8), pp. 1269–1277. [CrossRef]
Lan, S., Veiseh, M., and Zhang, M., 2005, “Surface Modification of Silicon and Gold-Patterned Silicon Surfaces for Improved Biocompatibility and Cell Patterning Selectivity,” Biosensors Bioelectron., 20(9), pp. 1697–1708. [CrossRef]
Metikoš-Huković, M., Kwokal, A., and Piljac, J., 2003, “The Influence of Niobium and Vanadium on Passivity of Titanium-Based Implants in Physiological Solution,” Biomaterials, 24(21), pp. 3765–3775. [CrossRef] [PubMed]
Aksakal, B., Yildirim, Ö. S., and Gul, H., 2004, “Metallurgical Failure Analysis of Various Implant Materials Used in Orthopedic Applications,” J. Failure Anal. Prevent., 4(3), pp. 17–23. [CrossRef]
Thalji, G., Gretzer, C., and Cooper, L. F., 2013, “Comparative Molecular Assessment of Early Osseointegration in Implant-Adherent Cells,” Bone, 52(1), pp. 444–453. [CrossRef] [PubMed]
Manivasagam, G., Dhinasekaran, D., and Rajamanickam, A., 2010, “Biomedical Implants: Corrosion and Its Prevention—A Review,” Recent Patents Corros. Sci., 2(1), pp. 40–54. [CrossRef]
Wu, B., and Shin, Y. C., 2007, “A One-Dimensional Hydrodynamic Model for Pressures Induced Near the Coating-Water Interface During Laser Shock Peening,” J. Appl. Phys., 101(2), pp. 23510–23515. [CrossRef]
Cao, Y., Shin, Y. C., and Wu, B., 2010, “Parametric Study on Single Shot and Overlapping Laser Shock Peening on Various Metals Via Modeling and Experiments,” ASME J. Manuf. Sci. Eng., 132(6), p. 061010. [CrossRef]
Ding, H., and Shin, Y. C., 2012, “Dislocation Density-Based Modeling of Subsurface Grain Refinement With Laser-Induced Shock Compression,” Comput. Mater. Sci., 53(1), pp. 79–88. [CrossRef]
Ye, C., and Cheng, G. J., 2012, “Scalable Patterning on Shape Memory Alloy by Laser Shock Assisted Direct Imprinting,” Appl. Surf. Sci., 258(24), pp. 10042–10046. [CrossRef]
Pence, C., Ding, H., Shen, N., and Ding, H., 2013, “Experimental Analysis of Sheet Metal Micro-Bending Using a Nanosecond-Pulsed Laser,” Int. J. Adv. Manuf. Technol., 69(1–4), pp. 1–9. [CrossRef]
Lu, J. Z., Luo, K. Y., Zhang, Y. K., Cui, C. Y., Sun, G. F., Zhou, J. Z., Zhang, L., You, J., Chen, K. M., and Zhong, J. W., 2010, “Grain Refinement of LY2 Aluminum Alloy Induced by Ultra-High Plastic Strain During Multiple Laser Shock Processing Impacts,” Acta Mater., 58(11), pp. 3984–3994. [CrossRef]
Lu, J. Z., Luo, K. Y., Zhang, Y. K., Sun, G. F., Gu, Y. Y., Zhou, J. Z., Ren, X. D., Zhang, X. C., Zhang, L. F., Chen, K. M., Cui, C. Y., Jiang, Y. F., Feng, A. X., and Zhang, L., 2010, “Grain Refinement Mechanism of Multiple Laser Shock Processing Impacts on ANSI 304 Stainless Steel,” Acta Mater., 58(16), pp. 5354–5362. [CrossRef]
Lu, J. Z., Zhong, J. W., Luo, K. Y., Zhang, L., Dai, F. Z., Chen, K. M., Wang, Q. W., Zhong, J. S., and Zhang, Y. K., 2011, “Micro-Structural Strengthening Mechanism of Multiple Laser Shock Processing Impacts on AISI 8620 Steel,” Mater. Sci. Eng. A, 528(19-20), pp. 6128–6133. [CrossRef]
Zhang, X. C., Zhang, Y. K., Lu, J. Z., Xuan, F. Z., Wang, Z. D., and Tu, S. T., 2010, “Improvement of Fatigue Life of Ti–6Al–4V Alloy by Laser Shock Peening,” Mater. Sci. Eng.: A, 527(15), pp. 3411–3415. [CrossRef]
Garbacz, H., Pisarek, M., and Kurzydłowski, K. J., 2007, “Corrosion Resistance of Nanostructured Titanium,” Biomol. Eng., 24(5), pp. 559–563. [CrossRef] [PubMed]
Nakai, M., Niinomi, M., Hieda, J., Yilmazer, H., and Todaka, Y., 2013, “Heterogeneous Grain Refinement of Biomedical Ti–29Nb–13Ta–4.6Zr Alloy Through High-Pressure Torsion,” Sci. Iran., 20(3), pp. 1067–1070 [CrossRef].
Huang, R., and Han, Y., 2013, “The Effect of SMAT-Induced Grain Refinement and Dislocations on the Corrosion Behavior of Ti–25Nb–3Mo–3Zr–2Sn Alloy,” Mater. Sci. Eng. C, 33(4), pp. 2353–2359. [CrossRef]
Kim, H. S., and Kim, W. J., 2014, “Annealing Effects on the Corrosion Resistance of Ultrafine-Grained Pure Titanium,” Corros. Sci., 89, pp. 331–337. [CrossRef]
Mishnaevsky, L., Levashov, E., Valiev, R. Z., Segurado, J., Sabirov, I., Enikeev, N., Prokoshkin, S., Solov'yov, A. V., Korotitskiy, A., Gutmanas, E., Gotman, I., Rabkin, E., Psakh'e, S., Dluhoš, L., Seefeldt, M., and Smolin, A., 2014, “Nanostructured Titanium-Based Materials for Medical Implants: Modeling and Development,” Mater. Sci. Eng. R, 81, pp. 1–19. [CrossRef]
Kumar, S., and Narayanan, T. S. N. S., 2008, “Corrosion Behaviour of Ti–15Mo Alloy for Dental Implant Applications,” J. Dentistry, 36(7), pp. 500–507. [CrossRef]
Singh, R., and Dahotre, N. B., 2007, “Corrosion Degradation and Prevention by Surface Modification of Biometallic Materials,” J. Mater. Sci., 18(5), pp. 725–751 [CrossRef].
Antunes, R. A., and de Oliveira, M. C. L., 2012, “Corrosion Fatigue of Biomedical Metallic Alloys: Mechanisms and Mitigation,” Acta Biomater., 8(3), pp. 937–962. [CrossRef] [PubMed]
Papakyriacou, M., 2000, “Effects of Surface Treatments on High Cycle Corrosion Fatigue of Metallic Implant Materials,” Int. J. Fatigue, 22(10), pp. 873–886. [CrossRef]
Schneider, G. B., Zaharias, R., Seabold, D., Keller, J., and Stanford, C., 2004, “Differentiation of Preosteoblasts is Affected by Implant Surface Microtopographies,” J. Biomed. Mater. Res. Part A, 69A(3), pp. 462–468. [CrossRef]
Masaki, C., Schneider, G. B., Zaharias, R., Seabold, D., and Stanford, C., 2005, “Effects of Implant Surface Microtopography on Osteoblast Gene Expression,” Clin. Oral Implants Res., 16(6), pp. 650–656. [CrossRef] [PubMed]
Rupp, F., Scheideler, L., Olshanska, N., de Wild, M., Wieland, M., and Geis-Gerstorfer, J., 2006, “Enhancing Surface Free Energy and Hydrophilicity Through Chemical Modification of Microstructured Titanium Implant Surfaces,” J. Biomed. Mater. Res. Part A, 76A(2), pp. 323–334. [CrossRef]
Olmedo, D. G., Duffó, G., Cabrini, R. L., and Guglielmotti, M. B., 2008, “Local Effect of Titanium Implant Corrosion: An Experimental Study in Rats,” Int. J. Oral Maxillofacial Surg., 37(11), pp. 1032–1038. [CrossRef]
Peyre, P., Scherpereel, X., Berthe, L., Carboni, C., Fabbro, R., Béranger, G., and Lemaitre, C., 2000, “Surface Modifications Induced in 316L Steel by Laser Peening and Shot-Peening. Influence on Pitting Corrosion Resistance,” Mater. Sci. Eng. A, 280(2), pp. 294–302. [CrossRef]
Pedrotti, F. L., and Pedrotti, L. S., 1993, Introduction to Optics, Prentice-Hall, Englewood Cliffs, NJ.
Ginzburg, V. L., 1961, Propagation of Electromagnetic Waves in Plasma, Gordon and Breach, New York.
Toth, L. S., Molinari, A., Estrin, Y., and Tóth, L. S., 2002, “Strain Hardening at Large Strains as Predicted by Dislocation Based Polycrystal Plasticity Model,” ASME J. Eng. Mater. Technol., 124(1), pp. 71–77. [CrossRef]
Baik, S. C., Estrin, Y., Kim, H. S., Jeong, H.-T., and Hellmig, R. J., 2002, “Calculation of Deformation Behavior and Texture Evolution During Equal Channel Angular Pressing of IF Steel Using Dislocation Based Modeling of Strain Hardening,” Mater. Sci. Forum, 408–412, pp. 697–702. [CrossRef]
Shen, N., and Ding, H., 2014, “Physics-Based Microstructure Simulation for Drilled Hole Surface in Hardened Steel,” ASME J. Manuf. Sci. Eng., 136(4), p. 044504. [CrossRef]
Ding, H., and Shin, Y. C., 2013, “Multi-Physics Modeling and Simulations of Surface Microstructure Alteration in Hard Turning,” J. Mater. Process. Technol., 213(6), pp. 877–886. [CrossRef]
Ding, H., Shen, N., and Shin, Y. C., 2012, “Predictive Modeling of Grain Refinement During Multi-Pass Cold Rolling,” J. Mater. Process. Technol., 212(5), pp. 1003–1013. [CrossRef]
Ding, H., and Shin, Y., 2014, “Dislocation Density-Based Grain Refinement Modeling of Orthogonal Cutting of Titanium,” ASME J. Manuf. Sci. Eng., 136(4), p. 041003. [CrossRef]
Davis, J. R., 1990, Properties and Selection: Nonferrous Alloys and Special-Purpose Materials, ASM International, Almere, The Netherlands.
Ding, H., and Shin, Y. C., 2012, “A Metallo-Thermomechanically Coupled Analysis of Orthogonal Cutting of AISI 1045 Steel,” ASME J. Manuf. Sci. Eng., 134(5), p. 51014. [CrossRef]
Evans, M. D., and Steele, J. G., 1997, “Multiple Attachment Mechanisms of Corneal Epithelial Cells to a Polymer—Cells can Attach in the Absence of Exogenous Adhesion Proteins Through a Mechanism That Requires Microtubules,” Exp. Cell Res., 233(1), pp. 88–98. [CrossRef] [PubMed]
Blawas, A. S., and Reichert, W. M., 1998, “Protein Patterning,” Biomaterials, 19(7-9), pp. 595–609. [CrossRef] [PubMed]
Craighead, H. G., James, C. D., and Turner, A. M. P., 2001, “Chemical and Topographical Patterning for Directed Cell Attachment,” Curr. Opinion Solid State Mater. Sci., 5(2–3), pp. 177–184. [CrossRef]
Thissen, H., Johnson, G., Hartley, P. G., Kingshott, P., and Griesser, H. J., 2006, “Two-Dimensional Patterning of Thin Coatings for the Control of Tissue Outgrowth,” Biomaterials, 27(1), pp. 35–43. [CrossRef] [PubMed]


Grahic Jump Location
Fig. 1

HEPLP micropatterning experimental setup. (a) Lasers and optics and (b) sandwich structured target material.

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Fig. 2

SEM image of the patterned cpTi surface

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Fig. 3

Scanned 3D maps and extracted 2D profile of untreated and treated cpTi surface. (a) 3D map of untreated surface, (b) 3D map of pattered surface, and (c) 2D profile across three plateaus on the pattered surface.

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Fig. 4

Microhardness tests for untreated and peened copper surface

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Fig. 5

Pressure history near the coating/confinement layer interface

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Fig. 6

Simulated shock wave pressure distribution at 4 ns

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Fig. 7

Dislocation density-based FE simulation results: (a) mesh grid model, (b) deformation (z-displacement, mm), (c) equivalent plastic strain, (d) dislocation density, ρtot (mm−2), (e) grain size, D (mm), (f) microhardness, and h (HV)

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Fig. 8

cpTi foil fixed on a copper cylinder fixture seeded with chondrocytes in cell culture chamber and the cell incubation

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Fig. 9

Comparison of SEM images of the patterned area and untreated flat surface on cpTi foil after cell culture test. (a) Patterned area and (b) original flat surface.

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Fig. 10

Different cell growing modes in the patterned area and untreated area. In (a), the outgrown (ellipse), outgrowing cells (rectangle) in the channel, and cells sitting on the wall of the channel (octagon) are highlighted. (a) Zoomed-in view in the channel, (b) an outgrowing cell in the channel, and (c) a no-outgrowth cell attached on the flat surface.




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