0
Research Papers

Laser-Energized Plasmonics for Nanopatterning Medical Devices

[+] Author and Article Information
P. A. Molian

Department of Mechanical and
Manufacturing Engineering,
St. Cloud State University,
St. Cloud, MN 56301
e-mail: pamolian@stcloudstate.edu

Contributed by the Manufacturing Engineering Division of ASME for publication in the JOURNAL OF MICRO- AND NANO-MANUFACTURING. Manuscript received January 16, 2015; final manuscript received May 19, 2015; published online June 24, 2015. Assoc. Editor: Nicholas Fang.

J. Micro Nano-Manuf 3(3), 031003 (Sep 01, 2015) (8 pages) Paper No: JMNM-15-1004; doi: 10.1115/1.4030680 History: Received January 16, 2015; Revised May 19, 2015; Online June 24, 2015

A scalable, prototype plasmonic nanomanufacturing system was designed, built, and tested for patterning nanostructures on the surfaces of drug-eluting stents (DES), the objective being to prevent the late-stent thrombosis (LST). Nanopatterning, unlike micro/macropatterning, of DES has proven to provide optimal, rapid, and preferential endothelial cell (EC) attachment (antithrombosis) while not significantly affecting shear-mediated platelet activation (prothrombosis). In this work, laser-induced, high-density surface plasmon polaritons (SPPs) were generated and utilized to produce nanostructures on the surfaces of DES by electric field enhancement mechanism. The scalability aspects such as downsizing the feature, improving the precision, increasing the throughput, and reducing the cost were investigated. Results indicated fairly uniform nanostructures; high throughput; excellent repeatability and resolution; significant cost savings; and potential for high retention of drug dose in the stent. The work represents an unprecedented area in nanomanufacturing where the basic science contribution is to harness the energy from plasmon polaritons by effectively “customizing” and “controlling” their propagation, while the engineering contribution is a scalability approach to reliably nanopattern medical devices in high volume with nanometer resolution. The nanomanufacturing system developed in this study may be an enabling technology to strongly impact other fields such as semiconductors, organic solar cells, and nano-electromechanical systems (NEMS).

FIGURES IN THIS ARTICLE
<>
Copyright © 2015 by ASME
Your Session has timed out. Please sign back in to continue.

References

Ozbay, E., 2006, “Plasmonics: Merging Photonics and Electronics at Nanoscale Dimensions,” Science, 311(5758), pp. 189–193. [CrossRef] [PubMed]
Zayatsa, A. V., Smolyaninov, I. I., and Maraduddin, A. A., 2005, “Nano-Optics of Surface Plasmon Polaritons,” Phys. Rep., 408(3–4), pp. 131–314. [CrossRef]
Fransilla, S., 2010, Introduction to Microfabrication, 2nd ed., Wiley, Chichester, UK, Chap. 1. [CrossRef]
Molian, P., Lin, Z., and Zou, Q., 2008, “Nano-Holes in Silicon Wafers Using Laser-Induced Surface Plasmon Polaritons,” J. Nanosci. Nanotechnol., 8(4), pp. 2163–2166. [CrossRef] [PubMed]
Simsek, E., and Akturk, S., 2011, “Plasmonic Enhancement During Femtosecond Laser Drilling of Sub-Wavelength Holes in Metals,” Plasmonics, 6(4), pp. 767–772. [CrossRef]
Valev, V. K., Denkova, D., Zheng, X., Kuznetsov, A., Reinhardt, C., Chichkov, B., Tsutsumanova, G., Osley, E., Petkov, V., de Clercq, B., Silhanek, A., Jeyaram, Y., Volskiy, V., Warburton, P., Vandenbosch, G., Russev, S., Aktsipetrov, O., Ameloot, M., Moshchalkov, V., and Verbiest, T., 2011, “Plasmon-Enhanced Sub-Wavelength Laser Ablation: Plasmonic Nanojets,” Adv. Mater., 24(10), pp. OP28–OP35. [CrossRef]
Garner, Q., and Molian, P., 2013, “Formation of Gold Microparticles by Ablation With Surface Plasmons,” Nanomaterials, 3(4), pp. 592–605. [CrossRef]
Park, K., Choi, H., Chang, C., Cohen, R., McKinley, G., and Barbastathis, G., 2012, “Nanotextured Silica Surfaces With Robust Superhydrophobicity and Omnidirectional Broadband Supertransmissivity,” ACS Nano, 6(5), pp. 3789–3799. [CrossRef] [PubMed]
Yang, H., Wang, Y., Fang, L., and Ge, S., 2011, “Laser Processing Technique of Stainless Steel Surface Nanotexture,” Adv. Sci. Lett., 4(3), pp. 891–894. [CrossRef]
Jeong, S., Hu, L., Lee, H., Garnett, E., Choi, J., and Cui, Y., 2010, “Fast and Scalable Printing of Large Area Monolayer Nanoparticles for Nanotexturing Applications,” Nano Lett., 10(8), pp. 2989–2994. [CrossRef] [PubMed]
Hausmann, U. P., Joerges, P., Heinzl, J., and Talke, F., 2009, “Nano-Texturing of Magnetic Recording Sliders Via Laser Ablation,” Microsyst. Technol., 15(10–11), pp. 1747–1751. [CrossRef]
Li, L., Guo, W., Wang, Z. B., Liu, Z., Whitehead, D., and Luk'yanchuk, B., 2009, “Large-Area Laser Nano-Texturing With User-Defined Patterns,” J. Micromech. Microeng., 19(5), p. 054002. [CrossRef]
Koch, J., Korte, F., Bauer, T., Fallnich, C., Ostendorf, A., and Chichkov, B. N., 2005, “Nanotexturing of Gold Films by Femtosecond Laser-Induced Melt Dynamics,” Appl. Phys. A: Mater. Sci. Process., 81(2), pp. 325–328. [CrossRef]
de Oliveira, P. T., and Nanci, A., 2004, “Nanotexturing of Titanium-Based Surfaces Upregulates Expression of Bone Sialoprotein and Osteopontin by Cultured Osteogenic Cells,” Biomaterials, 25(3), pp. 403–413. [CrossRef] [PubMed]
Buehler, M., and Molian, P., 2012, “Nanosecond Laser Induced Periodic Surface Structures on Drug Elution Profiles in Stents,” ASME J. Med. Devices, 6(3), p. 031002. [CrossRef]
Nair, R., Molian, V., and Molian, P., 2012, “Femtosecond Laser Nanotexturing of Drug Eluting Stents,” ASME J. Manuf. Sci. Eng., 134(6), p. 061008. [CrossRef]
Xie, Z., Yu, W., Wang, T., Zhang, H., Fu, Y., Liu, H., Li, F., Lu, Z., and Sun, Q., 2011, “Plasmonic Nanolithography: A Review,” Plasmonics, 6(3), pp. 565–580. [CrossRef]
Kim, Y., Kim, S., Jung, H., Lee, E., and Hahn, J., 2009, “Plasmonic Nano Lithography With a High Scan Speed Contact Probe,” Opt. Express, 17(22), pp. 19476–19485. [CrossRef] [PubMed]
Srituravanich, W., Pan, L., Wang, Y., Sun, C., Bogy, D. B., and Zhang, X., 2008, “Flying Plasmonic Lens in the Near Field for High-Speed Nanolithography,” Nat. Nanotechnol., 3(12), pp. 733–737. [CrossRef] [PubMed]
Genereux, P., and Mehran, R., 2009, “Are Drug-Eluting Stents Safe in the Long Term?,” Can. Med. Assoc. J., 180(2), pp. 154–155. [CrossRef]
Williams, D., Abbott, J., and Kip, K., 2006, “Outcomes of 6906 Patients Undergoing Percutaneous Coronary Intervention in the Era of Drug-Eluting Stents: Report of the DES Cover Registry,” Circulation, 114(20), pp. 2154–2162. [CrossRef] [PubMed]
Feres, F., Costa, J. R., Jr., and Abizaid, A., 2006, “Very Late Thrombosis After Drug-Eluting Stents,” Catheterization Cardiovasc. Interventions, 68(1), pp. 83–88. [CrossRef]
Lamers, E., van Horssen, R., van Delft, F., Luttge, R., Walboomers, X. F., and Jansen, J. A., 2010, “The Influence of Nanoscale Topographical Cues on Initial Osteoblast Morphology and Migration,” Eur. Cells Mater., 20, pp. 329–343.
Ravichandran, R., Liao, S., Ng, C., Chan, C., Raghunath, M., and Ramakrishna, S., 2009, “Effects of Nanotopography on Stem Cell Phenotypes,” World J. Stem Cells, 1(1), pp. 55–66. [CrossRef] [PubMed]
Miller, D. C., Haberstroh, K. M., and Webster, T. J., 2007, “PLGA Nanometer Surface Features Manipulate Fibronectin Interactions for Improved Vascular Cell Adhesion,” J. Biomed. Mater. Res., Part A, 81(3), pp. 678–684. [CrossRef]
Chung, B. G., Kang, L., and Khademhosseini, A., 2007, “Micro- and Nanoscale Technologies for Tissue Engineering and Drug Discovery Applications,” Expert Opin. Drug Discov., 2(12), pp. 1653–1668. [CrossRef] [PubMed]
Owens, G., 2008, “Nanoporous Stents With Enhanced Cellular Adhesion and Reduced Neointimal Formation,” U.S. Patent No. 20080086198.
Liu, Y. F., 2005, “Laser-Assisted Nanoscale Material Processing,” ASME Paper No. IMECE2005-83047. [CrossRef]
West, P. R., Ishi, S., Naik, G., Emani, N., Shalaev, V., and Boltasseva, A., 2010, “Searching for Better Plasmonic Materials,” Lasers Photonics Rev., 4(6), pp. 795–808. [CrossRef]
Phadke, M. S., 1989, Quality Engineering Using Robust Design, Prentice Hall International, Englewood Cliffs, NJ.
Kong, D., Eisenstein, E., Sketch, M., Jr., Zidar, J., Ryan, T., Harrington, R., Newman, M., Smith, P., Mark, D., and Califf, R., 2004, “Economic Impact of Drug Eluting Stents on Hospital Systems: A Disease-State Model,” Am. Heart J., 147(3), pp. 449–456. [CrossRef] [PubMed]
Kuukasjärvi, P., Räsänen, P., Malmivaara, A., and Aronen, P., 2007, “Economic Evaluation of Drug-Eluting Stents: A Systematic Literature Review and Model-Based Cost-Utility Analysis,” Int. J. Technol. Assess. Health Care, 23(4), pp. 473–479. [PubMed]
“ Drug Eluting Stents: An Economic Evaluation,” Last accessed May 18, 2015, http://www.cadth.ca/media/pdf/372_drug_eluting_stents_ov_e.pdf
Dobesh, P. P., Stacy, Z. A., Ansara, A. J., and Enders, J. M., 2004, “Drug-Eluting Stents: A Mechanical and Pharmacologic Approach to Coronary Artery Disease,” Last accessed May 18, 2015, http://www.medscape.com/viewarticle/495864_8
Mensah, G., and Brown, D., 2007, “An Overview of Cardiovascular Disease Burden in the United States,” Health Aff., 26(1), pp. 38–48. [CrossRef]

Figures

Grahic Jump Location
Fig. 1

Schematic of plasmonic nanomanufacturing: (a) process and (b) system

Grahic Jump Location
Fig. 5

Light intensity distribution at (a) 20 nm below the exit of hole and (b) 50 nm below the exit of hole. The location of mask is at the edge of the nanohole.

Grahic Jump Location
Fig. 7

Plasmonic lens: (a) alumina membrane containing nanoarray holes and (b) complete plasmonic lens where aluminum is sputtered on alumina membrane and supported on a quartz substrate; the lens is mounted on an optical holder

Grahic Jump Location
Fig. 6

(a) A schematic of laboratory plasmonics nanomanufacturing system for scalability studies and (b) a photograph of laboratory plasmonics nanomanufacturing system for scalability studies

Grahic Jump Location
Fig. 4

Laser-energized plasmonic nanopatterned nitinol showing 60–80 nm features

Grahic Jump Location
Fig. 3

Phase contrast AFM images of chemically etched sample in to reveal nanostructures in silicon

Grahic Jump Location
Fig. 2

SEM images of silicon with SU-8 photoresist: (a) before plasmonics patterning and (b) after plasmonics patterning

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In