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Research Papers

Predicting the Force Needed to Create a Compression Seal in an Ultrathin Elastoviscoplastic Membrane

[+] Author and Article Information
Patrick S. McNeff

School of Mechanical, Industrial, and
Manufacturing Engineering,
Oregon State University,
2000 SW Monroe Ave,
204 Rogers Hall,
Corvallis, OR 97331-6001
e-mail: mcneffp@oregonstate.edu

Brian K. Paul

School of Mechanical, Industrial,
and Manufacturing Engineering,
Oregon State University,
2000 SW Monroe Ave,
204 Rogers Hall,
Corvallis, OR 97331-6001
e-mail: brian.paul@oregonstate.edu

1Corresponding author.

Contributed by the Manufacturing Engineering Division of ASME for publication in the JOURNAL OF MICRO- AND NANO-MANUFACTURING. Manuscript received September 27, 2016; final manuscript received December 5, 2016; published online January 10, 2017. Editor: Jian Cao.

J. Micro Nano-Manuf 5(1), 011005 (Jan 10, 2017) (5 pages) Paper No: JMNM-16-1053; doi: 10.1115/1.4035474 History: Received September 27, 2016; Revised December 05, 2016

In this paper, a finite element model is developed, and experimentally validated, for predicting the force required to produce a compression seal between a polycarbonate sealing boss and a 25-μm thick elastoviscoplastic hemodialysis membrane. This work leverages previous efforts to determine the conditions for hermetic sealing in a microchannel hemodialyzer fabricated using hot-embossed polycarbonate microchannel laminae containing sealing boss features. Methods are developed for mechanically characterizing the thin elastoviscoplastic hemodialysis membrane. The experimental data for assessing the depth of penetration into the membrane as a function of force show an R2 value of 0.85 showing good repeatability. The average percent error was found to be −8.0% with a range between −21.9% and 4.4% error in the strain region of interest.

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References

Rundel, J. T. , Paul, B. K. , and Remcho, V. T. , 2007, “ Organic Solvent Nanofiltration for Microfluidic Purification of Poly(Amidoamine) Dendrimers,” J. Chromatogr. A, 1162(2), pp. 167–174. [CrossRef] [PubMed]
Tuhy, A. R. , Anderson, E. K. , and Jovanovic, G. N. , 2012, “ Urea Separation in Flat-Plate Microchannel Hemodialyzer; Experiment and Modeling,” Biomed. Microdevices, 14(3), pp. 595–602. [CrossRef] [PubMed]
Paul, B. K. , Abhinkar, B. S. , and Lee, S. , 2011, “ High Pressure Hermetic Compression Seals for Embedding Elastomeric Membrane Microvalves in Polymer Microfluidic Devices,” Precis. Eng., 35(2), pp. 348–354. [CrossRef]
Zhao, W. , Liu, C. , Wu, F. , and Lenardi, C. , 2014, “ Investigation on the Mechanical Behavior of Poly(2-Hydroxyethyl Methacrylate) Hydrogel Membrane Under Compression in the Assembly Process of Microfluidic System,” J. Polym. Sci. Part B: Polym. Phys., 52(7), pp. 485–495. [CrossRef]
Paul, B. K. , and Ward, D. K. , 2014, “ The Hermeticity of Compression Seals in Microchannel Hemodialyzers,” ASME J. Micro Nano-Manuf., 2(3), p. 031006. [CrossRef]
Thomas, M. , Moriyama, K. , and Ledebo, I. , 2011, “ AN69: Evolution of the World's First High Permeability Membrane,” Contrib. Nephrol., 173, pp. 119–129. [PubMed]
Herrera-Gutiérrez, M. E. , Seller-Pérez, G. , Verdu, D. A. , Jironda-Gallegos, C. , Verdu, D. A. , Jironda-Gallegos, C. , Martín-Velázquez, M. , and Quesada-García, G. , 2012, “ Dialysis Efficiency of AN69, a Semisynthetic Membrane Not Well Suited for Diffusion,” ISRN Nephrol., 2013, p. e185989.
McPhatter, L. L. , Lockridge, R. S., Jr. , Albert, J. , Anderson, H. , Craft, V. , Jennings, F. M. , Spencer, M. , Swafford, A. , Barger, T. , and Coffey, L. , 1999, “ Nightly Home Hemodialysis: Improvement in Nutrition and Quality of Life,” Adv. Renal Replacement Ther., 6(4), pp. 358–365.
McNeff, P. S. , and Paul, B. K. , 2015, “ Determining the Compressive Behavior of an Ultra-Thin Elastoviscoplastic Membrane Used in Sealing a Microchannel Hemodialyzer,” ASME Paper No. ICNMM2015-48366.
Jin, M. T. , and Chen, L. , 2012, “ Compressive Strength and SEM Observations of Geopolymers Reinforced by Carbon Fibers, Polyacrylonitrile Fibers and Cellulose Fibers,” Adv. Mater. Res., 472–475, pp. 570–574. [CrossRef]
Young, W. C. , Roark, R. J. , and Budynas, R. G. , 2002, Roark's Formulas for Stress and Strain, McGraw-Hill, New York, Chap. 8.
Marlow, R. S. , 2003, “ A General First-Invariant Hyperelastic Constitutive Model,” Third European Conference on Constitutive Models for Rubber, London, Vol. 3, pp. 156–160.

Figures

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Fig. 1

One layer schematic of our microfluidic architecture. Sealing bosses are circled.

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Fig. 2

Compression testing results for 1 × 1 cm square stacks of AN-69ST membrane, averaged over 12 tests. Standard error bars shown.

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Fig. 3

Plastic strain as a function of total strain from elastic plastic experiments. Standard error bars and trend line equation included.

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Fig. 4

Experimental setup for validation experiments

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Fig. 5

Photochemically machined boss imaged on a white light interferometric microscope. The z-axis (in μm) has been exaggerated for better visualization of the boss geometry.

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Fig. 6

Typical CPS profile scan: (left) top view; (right) 3D rendering

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Fig. 7

Initial geometry of the FEA model of a rigid boss into single layer deformable membrane. Bottom of membrane was fixed while the rigid boss was given a displacement. The corresponding force on the platen was recorded as a function of displacement.

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Fig. 8

FEA result showing strain field around the boss at 0.05 strain

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Fig. 9

Graph of force per centimeter boss as a function of CDD strain into the membrane showing abaqus results (circles with trend line) and experimental validation (diamonds with run number). Standard error bars are plotted for the estimated CDD strain.

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