Episcleral venous pressure (EVP) refers to the pressure in the episcleral veins. It is used by scientists in glaucoma physiology and pharmacology research to study the parameters of aqueous humor dynamics as part of the Goldmann equation [1]. The episcleral veins drain into the superior ophthalmic vein which drains into the cavernous sinus. Our previous work in a pig model [2] shows for the first time that EVP is an excellent non-invasive quantitative marker for intracranial pressure (ICP) estimation (high ICP leads to high intracranial venous pressure and high EVP). Intracranial pressure (ICP) is an important marker of outcomes in traumatic brain injury. There is an unfulfilled civilian and military need for a non-invasive ICP measurement modality. EVP could serve as a quantitative ICP biomarker, measurable by personnel with different skill levels for remote acute triage in battlefields and other urgent situations.

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