Cyber-physical-social systems (CPSS) with highly integrated functions of sensing, actuation, computation, and communication are becoming the mainstream consumer and commercial products. The performance of CPSS heavily relies on the information sharing between devices. Given the extensive data collection and sharing, security and privacy are of major concerns. Thus one major challenge of designing those CPSS is how to incorporate the perception of trust in product and systems design. Recently a trust quantification method was proposed to measure trustworthiness of CPSS by quantitative metrics of ability, benevolence, and integrity. In this paper, the applications of ability and benevolence metrics in design optimization of CPSS architecture are demonstrated. A Bayesian optimization method is developed to perform trust based CPSS network design, where the most trustworthy network with respect to a reference node can be selected to collaborate and share information with.