With an increased effort within the engineering community to design molecular machines, it has become clear that a specific, external control method is required. Here we propose a simple mechanism for a molecular switch involving conjugating a molecule within the machinery to a gold nanorod. Then actuate that machinery’s active state by affecting a change in the conjugated molecule. We demonstrate the feasibility of the method using a fluorescent probe, and we report on progress we have made toward demonstrating it with a protein.
Biomolecular Activity Switch: An Application of Metallic Nanoparticle Plasmon Resonance and Femtosecond Pulsed Lasers
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Alper, J, & Hamad-Schifferli, K. "Biomolecular Activity Switch: An Application of Metallic Nanoparticle Plasmon Resonance and Femtosecond Pulsed Lasers." Proceedings of the ASME 2008 International Mechanical Engineering Congress and Exposition. Volume 2: Biomedical and Biotechnology Engineering. Boston, Massachusetts, USA. October 31–November 6, 2008. pp. 255-257. ASME. https://doi.org/10.1115/IMECE2008-68104
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