Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 °C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uniaxial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined.
Effect of Controlled Rate Freezing on the Microstructural Properties of Poly (L-lactic Acid) Scaffolds
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Chinnasami, H, Idicula, G, Hayes, D, & Devireddy, R. "Effect of Controlled Rate Freezing on the Microstructural Properties of Poly (L-lactic Acid) Scaffolds." Proceedings of the ASME 2012 International Mechanical Engineering Congress and Exposition. Volume 2: Biomedical and Biotechnology. Houston, Texas, USA. November 9–15, 2012. pp. 651-656. ASME. https://doi.org/10.1115/IMECE2012-87558
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