Current efforts in medical diagnostic technology focus toward developing biological sensors with the capacity for detecting trace quantities of specified organic molecules. In this study, metallic nanoparticles were investigated for the development of field-enhanced chemical and biological detection devices with the capacity to achieve single-molecule level detection resulting from surface enhanced Raman scattering (SERS) associated with closely spaced noble metal nanostructures.[1, 2] Localized surface plasmon resonance (LSPR) sensors likewise benefit from the incorporation of ordered metal nanoparticles on surfaces, providing increased shift in minimum of reflectivity with biological binding event (figure 1).[3]

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