Glaucoma is a leading cause of blindness worldwide. Some of the chief clinical hallmarks of glaucoma are the permanent posterior cupping of the optic nerve head, in the posterior pole of the eye, and the accompanying damage to the lamina cribrosa — the fenestrated structure of connective tissue spanning the scleral canal that provides structural support to the axon bundles passing through it. While elevated intraocular pressure (IOP) is associated with this disease, its role remains unclear. It has been hypothesized that IOP-related stress and strain within the laminar connective tissue (LCT) underlie the onset and progression of glaucoma  and that they may be used to predict the location of axonal insult and the pattern of damage within the LCT.
- Bioengineering Division
Large Scale Voxel-Based Finite Element Modeling of Normal and Early Glaucomatous Monkey Lamina Cribrosa
- Views Icon Views
- Share Icon Share
- Search Site
Kodiyalam, S, Roberts, MD, Sigal, IA, Hart, RT, Burgoyne, CF, & Downs, JC. "Large Scale Voxel-Based Finite Element Modeling of Normal and Early Glaucomatous Monkey Lamina Cribrosa." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 553-554. ASME. https://doi.org/10.1115/SBC2008-192984
Download citation file: