Atherosclerosis is a disease characterized by arterial plaques that include several components of which the necrotic core has been recognized as an important indicator of the likelihood of plaque rupture [1]. In the present study, the relation of hemodynamic wall shear stress (WSS) to necrotic core localization in the left coronary artery of patients was investigated using intravascular ultrasound (IVUS) and computational fluid dynamics (CFD). An innovative 3D measuring technique was developed and was successfully used to reconstruct coronary arteries in patients based on angiographic images and echo ultrasound slices from IVUS. The reconstruction includes lumen, external elastic membrane (EEM) and spatial distribution of plaque components such as fibrous tissue, necrotic core and calcium. WSS distribution in the vessel segment was computed by CFD, and the relative locations of necrotic core and WSS were determined. Results to date support the hypothesis that a greater necrotic core in coronary plaques is associated with areas of low WSS. The methodology developed has implications for the study of plaque progression and the prediction of likelihood of plaque rupture.
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Relation Between Wall Shear Stress and Plaque Necrotic Core in the Left Coronary Arteries of Patients Using Intravascular Ultrasound and Computational Fluid Dynamics
Jin Suo,
Jin Suo
Georgia Tech and Emory University, Atlanta, GA
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Michael McDaniel,
Michael McDaniel
Emory University School of Medicine, Atlanta, GA
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Habib Samady,
Habib Samady
Emory University School of Medicine, Atlanta, GA
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Don Giddens
Don Giddens
Georgia Tech and Emory University, Atlanta, GA
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Jin Suo
Georgia Tech and Emory University, Atlanta, GA
Michael McDaniel
Emory University School of Medicine, Atlanta, GA
Habib Samady
Emory University School of Medicine, Atlanta, GA
Don Giddens
Georgia Tech and Emory University, Atlanta, GA
Paper No:
SBC2008-192382, pp. 875-876; 2 pages
Published Online:
March 13, 2014
Citation
Suo, J, McDaniel, M, Samady, H, & Giddens, D. "Relation Between Wall Shear Stress and Plaque Necrotic Core in the Left Coronary Arteries of Patients Using Intravascular Ultrasound and Computational Fluid Dynamics." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 875-876. ASME. https://doi.org/10.1115/SBC2008-192382
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