Geometric Analysis and Decomposition of Normal and Hypertensive Human Right Ventricle From Diagnostic Medical Imaging

Pulmonary hypertension (PH) is a cardio-pulmonary illness which affects all ages and racial populations, and induces significant changes to right ventricle (RV) shape and function. As such, the functional state of the RV is commonly thought to be a major determinant of symptoms and survival rates for PH. However, there has been little success to-date to identify clinically obtainable metrics of RV shape and deformation as a means to detect the onset and progression of PH. This difficulty is heightened by the complexity of RV shapes, which continues to confound basic and clinical scientists.