Physiological flow parameters such as pressure and stress inside the vascular system strongly influence the physiology and function of vascular endothelial cells [1]. Variations in the shear stress experienced by endothelial cells affect morphology, alignment with the flow, mechanical strength, rate of proliferation, and gene expression [2]. Although it is known that these factors are dependent on the hemodynamics of the flow, the relationship has not been accurately quantified. In vitro bioreactor flow loops have been developed to simulate vascular flow for tissue conditioning and measurement of the endothelial cell response to varying shear [3–5]; however, wall shear stresses (WSS) have been estimated from the bulk flow rate by assuming Poiseuille flow [2, 6]. Due to the pulsatility of the flow, biochemical interactions, and the typically short vessel length, this assumption is fundamentally incorrect; however, the level of inaccuracy has not been quantified.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Wall Shear Stress Measurements in an Arterial Flow Bioreactor
Elizabeth Voigt,
Elizabeth Voigt
Virginia Tech, Blacksburg, VA
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Cara Buchanan,
Cara Buchanan
Virginia Tech, Blacksburg, VA
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Jaime Schmieg,
Jaime Schmieg
Virginia Tech, Blacksburg, VA
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M. Nichole Rylander,
M. Nichole Rylander
Virginia Tech, Blacksburg, VA
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Pavlos Vlachos
Pavlos Vlachos
Virginia Tech, Blacksburg, VA
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Elizabeth Voigt
Virginia Tech, Blacksburg, VA
Cara Buchanan
Virginia Tech, Blacksburg, VA
Jaime Schmieg
Virginia Tech, Blacksburg, VA
M. Nichole Rylander
Virginia Tech, Blacksburg, VA
Pavlos Vlachos
Virginia Tech, Blacksburg, VA
Paper No:
SBC2011-53333, pp. 1143-1144; 2 pages
Published Online:
July 17, 2013
Citation
Voigt, E, Buchanan, C, Schmieg, J, Rylander, MN, & Vlachos, P. "Wall Shear Stress Measurements in an Arterial Flow Bioreactor." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 1143-1144. ASME. https://doi.org/10.1115/SBC2011-53333
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