Long-term cryopreservation of functional engineered tissues (ETs) is a key enabling technology for tissue engineering and regenerative medicine. However, a limited understanding of tissue-level biophysical phenomena during freeze/thaw (F/T) and their effects on cells and ECM microstructure poses significant challenges for i) preserving tissue functionality, and ii) controlling highly tissue-type dependent cryopreservation outcomes.
- Bioengineering Division
Effects of Freezing-Induced Cell-Fluid-Matrix Interactions on Cells and Extracellular Matrix of Engineered Tissues
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Teo, KY, Dutton, JC, Grinnell, F, & Han, B. "Effects of Freezing-Induced Cell-Fluid-Matrix Interactions on Cells and Extracellular Matrix of Engineered Tissues." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 133-134. ASME. https://doi.org/10.1115/SBC2011-53407
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