The uncontrolled growth of cancer cells within a confined tissue space generates residual stresses in solid tumors [1,2]. These stresses contribute to tumor progression, pathological cellular behavior, and compression of lymphatic and blood vessels [3–5]. A major consequence of vascular compression is a decrease in pathways available for blood flow and delivery of diagnostic and therapeutic agents, resulting in insufficient and heterogeneous delivery of chemotherapy and nanomedicine. The reduced perfusion also causes hypoxia and acidity — two important barriers to treatment efficacy and promoters of malignancy. In this work, we developed a strategy to quantify growth-induced residual stresses in tumors and investigate whether stress levels affect tumor growth rate and delivery of therapeutic agents. We found that stress levels are elevated in solid tumors and are sufficient to cause the collapse of blood vessels. In addition high stress levels were correlated to slower tumor growth.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Residual Stresses in Solid Tumors: Implications to Tumor Growth and Drug Delivery
Triantafyllos Stylianopoulos,
Triantafyllos Stylianopoulos
Harvard Medical School-Massachusetts General Hospital, Boston, MA
University of Cyprus, Nicosia, Cyprus
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John D. Martin,
John D. Martin
Harvard Medical School-Massachusetts General Hospital, Boston, MA
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Vikash P. Chauhan,
Vikash P. Chauhan
Harvard Medical School-Massachusetts General Hospital, Boston, MA
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Lance L. Munn,
Lance L. Munn
Harvard Medical School-Massachusetts General Hospital, Boston, MA
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Rakesh K. Jain
Rakesh K. Jain
Harvard Medical School-Massachusetts General Hospital, Boston, MA
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Triantafyllos Stylianopoulos
Harvard Medical School-Massachusetts General Hospital, Boston, MA
University of Cyprus, Nicosia, Cyprus
John D. Martin
Harvard Medical School-Massachusetts General Hospital, Boston, MA
Vikash P. Chauhan
Harvard Medical School-Massachusetts General Hospital, Boston, MA
Lance L. Munn
Harvard Medical School-Massachusetts General Hospital, Boston, MA
Rakesh K. Jain
Harvard Medical School-Massachusetts General Hospital, Boston, MA
Paper No:
SBC2012-80235, pp. 207-208; 2 pages
Published Online:
July 19, 2013
Citation
Stylianopoulos, T, Martin, JD, Chauhan, VP, Munn, LL, & Jain, RK. "Residual Stresses in Solid Tumors: Implications to Tumor Growth and Drug Delivery." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 207-208. ASME. https://doi.org/10.1115/SBC2012-80235
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