Many native and bioengineered soft tissues are composed of two or more types of biopolymer networks that mechanically define and support the material . Modeling the response of multi-network soft tissues to mechanical loading can be difficult due to the heterogeneous nature of these materials and the large strains (>1) involved. As tissues deform, the different biopolymer networks interact with one another and determine the overall stress-strain outcome for the tissue. Capturing this interaction could help improve the accuracy of a computer model to simulate the microscale behavior of soft tissues under load. We have developed a two-network model to reflect interactions between collagen and fibrin biopolymer networks loaded in uniaxial extension. The model can help improve our understanding of native and engineered tissue mechanics.
- Bioengineering Division
A Microscale Collagen-Fibrin Interacting Network Model With Comparison to Experimental Results
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Hyypio, JD, Hadi, MF, Lai, VK, & Barocas, VH. "A Microscale Collagen-Fibrin Interacting Network Model With Comparison to Experimental Results." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 763-764. ASME. https://doi.org/10.1115/SBC2012-80656
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