Mechanical circulatory support (MCS) devices, such as the total artificial heart and ventricular assist devices, are employed as bridge-to-transplant or destination therapies for advanced heart failure. Recipients of these life-saving MCS devices have to endure life-long antiplatelet regimens to counteract thromboembolic events resulting from exposure of platelets to high shear stress. Often, large animal models, i.e. bovine and ovine, have been utilized to evaluate the performance and blood compatibility of these cardiovascular devices. Therefore, understanding and correlating the interspecies differences of platelet reactivity is crucial in optimizing the design of MCS devices.
- Bioengineering Division
Platelet Activity State in Human, Bovine, and Ovine Species Under Constant Shear Stress: A Comparative Study
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Tran, PL, Merkle, VM, DeCook, T, Hutchinson, M, Sheriff, J, Bluestein, D, & Slepian, MJ. "Platelet Activity State in Human, Bovine, and Ovine Species Under Constant Shear Stress: A Comparative Study." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT03A006. ASME. https://doi.org/10.1115/SBC2013-14825
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