Rupture of aneurysms is a leading cause of death in the United States. Extensive biomechanical studies have shown that mechanical stress in aneurysm walls plays a critical role in the rupture of aneurysms. Highly elevated local stress and degraded aneurismal walls are believed to make aneurysms vulnerable to rupture [1–3]. Asymmetric aneurysms with irregular shape and wall thickness are vulnerable to rupture. Aneurismal arteries are often tortuous such as in the Loeys-Dietz syndrome , but the mechanism is unclear.
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Aneurismal Arteries are Vulnerable to Mechanical Buckling
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Han, H, Lee, AY, Shadfan, RH, & Xiao, Y. "Aneurismal Arteries are Vulnerable to Mechanical Buckling." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT04A003. ASME. https://doi.org/10.1115/SBC2013-14192
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