With the advancement of experimental and computational techniques, three-dimensional (3D) computational fluid dynamics (CFD) airflow models of the respiratory system have increasingly been used to evaluate aerosol deposition, gas exchange and airflow characteristics under various physiological and/or disease conditions. One specific application that is emerging in the field of toxicology is assessing the risk for exposure to highly reactive, water-soluble gases and vapors including formaldehyde, acetaldehyde, hydrogen sulfide, and acrolein by coupling CFD models of nasal airways of rats and humans to physiological based pharmacokinetic (PBPK) models.
- Bioengineering Division
Uptake of Soluble Gases in the Entire Respiratory Systems of Rats and Humans Using Transient CFD/PBPK Models
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Kabilan, S, Kuprat, A, Einstein, D, Carson, J, Jacob, R, Minard, K, & Corley, R. "Uptake of Soluble Gases in the Entire Respiratory Systems of Rats and Humans Using Transient CFD/PBPK Models." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT25A004. ASME. https://doi.org/10.1115/SBC2013-14548
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