Biomaterial scaffolds that present defined microenvironmental cues (e.g., nano-topography) to cells have shown promise for a variety of tissue engineering applications. However, the specific cues best suited for promoting the formation of aligned, fibrous tissues such as tendon are not fully understood. In this study, we utilize a micro-photopatterning (μPP) model system to precisely arrange scaffold-mimicking microenvironmental cues and investigate their role in the formation of tendon-like neo-tissues. Our data show that scaffold architectural features at both nano- and micro-length scales may be important parameters for directing tendon-like cell organization and the formation of aligned, fibrillar collagen.

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