Most arterial mechanics studies have focused on excised non-coronary vessels, with few studies validating the application of ex-vivo results to in-vivo conditions. A method was developed for testing the mechanical properties of intact left anterior descending coronary arteries under a variety of conditions. Vascular deformation and pressure were simultaneously measured with intravascular ultrasound and a pressure transducer guidewire, respectively. Results suggest the importance of understanding in-vivo factors such as myocardial support, vascular tone and local pressure fluctuations when applying ex-vivo coronary characterization data. With further development, this method can more accurately characterize the true in-vivo constitutive behavior in normal and atherosclerotic coronaries.
A Novel Experimental Method to Estimate Stress-Strain Behavior of Intact Coronary Arteries Using Intravascular Ultrasound (IVUS)
Contributed by the Bioengineering Division for publication in the Journal of Biomechanical Engineering. Manuscript received Nov. 2001; revised manuscript received Sept. 2002. Associate Editor: J. D. Humphrey.
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Tajaddini, A., Kilpatrick, D. L., and Vince, D. G. (February 14, 2003). "A Novel Experimental Method to Estimate Stress-Strain Behavior of Intact Coronary Arteries Using Intravascular Ultrasound (IVUS) ." ASME. J Biomech Eng. February 2003; 125(1): 120–123. https://doi.org/10.1115/1.1536929
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