Biaxial testing, histological measurements and theoretical continuum mechanics modeling were employed to investigate the structure and mechanical properties of the mitral valve leaflet-strut chordae transition zone (LCT). The results showed that geometry changes and collagen fiber angle distribution contribute to variations in mechanical properties in the LCT zone. A simple three-coefficient exponential constitutive law was able to simulate the variation in stress-stretch behavior in the LCT zone by spatially varying a single coefficient and incorporating collagen fiber angle and degree of alignment. This quantitative information can greatly improve the predictions from biomechanical valve models by incorporating regional variations of structure and properties in the mitral leaflet-chordae tendineae system. These data provide the foundation for a computational model for studying stress distributions before and following chordal rupture, which may indicate the underlying reasons for the development of valve insufficiency in patients.
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April 2004
Technical Papers
The Structure and Mechanical Properties of the Mitral Valve Leaflet-Strut Chordae Transition Zone
Ling Chen,
Ling Chen
Department of Mechanical Engineering, San Diego State University, San Diego, CA, 92182-1323
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Frank C-P. Yin, M.D., Ph.D.,
Frank C-P. Yin, M.D., Ph.D.
Department of Biomechanical Engineering, Washington University, St. Louis, MO 63130
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Karen May-Newman, Ph.D.
Karen May-Newman, Ph.D.
Department of Mechanical Engineering, San Diego State University, San Diego, CA, 92182-1323
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Ling Chen
Department of Mechanical Engineering, San Diego State University, San Diego, CA, 92182-1323
Frank C-P. Yin, M.D., Ph.D.
Department of Biomechanical Engineering, Washington University, St. Louis, MO 63130
Karen May-Newman, Ph.D.
Department of Mechanical Engineering, San Diego State University, San Diego, CA, 92182-1323
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division February 12, 2003; revision received October 24, 2003. Associate Editor: M. Sacks.
J Biomech Eng. Apr 2004, 126(2): 244-251 (8 pages)
Published Online: May 4, 2004
Article history
Received:
February 12, 2003
Revised:
October 24, 2003
Online:
May 4, 2004
Citation
Chen, L., Yin, M.D., Ph.D., F. C., and May-Newman, Ph.D., K. (May 4, 2004). "The Structure and Mechanical Properties of the Mitral Valve Leaflet-Strut Chordae Transition Zone ." ASME. J Biomech Eng. April 2004; 126(2): 244–251. https://doi.org/10.1115/1.1695569
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