The Arrhenius and thermal isoeffective dose (TID) models are the two most commonly used models for predicting hyperthermic injury. The TID model is essentially derived from the Arrhenius model, but due to a variety of assumptions and simplifications now leads to different predictions, particularly at temperatures higher than . In the present study, the two models are compared and their appropriateness tested for predicting hyperthermic injury in both the traditional hyperthermia (usually, ) and thermal surgery (or thermal therapy/thermal ablation, usually, ) regime. The kinetic parameters of thermal injury in both models were obtained from the literature (or literature data), tabulated, and analyzed for various prostate and kidney systems. It was found that the kinetic parameters vary widely, and were particularly dependent on the cell or tissue type, injury assay used, and the time when the injury assessment was performed. In order to compare the capability of the two models for thermal injury prediction, thermal thresholds for complete killing (i.e., 99% cell or tissue injury) were predicted using the models in two important urologic systems, viz., the benign prostatic hyperplasia tissue and the normal porcine kidney tissue. The predictions of the two models matched well at temperatures below . At higher temperatures, however, the thermal thresholds predicted using the TID model with a constant value of 0.5, the value commonly used in the traditional hyperthermia literature, are much lower than those predicted using the Arrhenius model. This suggests that traditional use of the TID model (i.e., ) is inappropriate for predicting hyperthermic injury in the thermal surgery regime . Finally, the time-temperature relationships for complete killing (i.e., 99% injury) were calculated and analyzed using the Arrhenius model for the various prostate and kidney systems.
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e-mail: xmhe@sc.edu
e-mail: bischof@umn.edu
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July 2009
Technical Briefs
Thermal Therapy in Urologic Systems: A Comparison of Arrhenius and Thermal Isoeffective Dose Models in Predicting Hyperthermic Injury
Xiaoming He,
Xiaoming He
Department of Mechanical Engineering, and Biomedical Engineering Program,
e-mail: xmhe@sc.edu
University of South Carolina
, Columbia, SC 29208
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Sankha Bhowmick,
Sankha Bhowmick
Department of Mechanical Engineering, and Biomedical Engineering and Biotechnology Program,
University of Massachusetts Dartmouth
, North Dartmouth, MA 02747
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John C. Bischof
John C. Bischof
Department of Mechanical Engineering, Department of Urologic Surgery, and Department of Biomedical Engineering,
e-mail: bischof@umn.edu
University of Minnesota
, Minneapolis, MN 55455
Search for other works by this author on:
Xiaoming He
Department of Mechanical Engineering, and Biomedical Engineering Program,
University of South Carolina
, Columbia, SC 29208e-mail: xmhe@sc.edu
Sankha Bhowmick
Department of Mechanical Engineering, and Biomedical Engineering and Biotechnology Program,
University of Massachusetts Dartmouth
, North Dartmouth, MA 02747
John C. Bischof
Department of Mechanical Engineering, Department of Urologic Surgery, and Department of Biomedical Engineering,
University of Minnesota
, Minneapolis, MN 55455e-mail: bischof@umn.edu
J Biomech Eng. Jul 2009, 131(7): 074507 (12 pages)
Published Online: June 5, 2009
Article history
Received:
November 9, 2008
Revised:
January 23, 2009
Published:
June 5, 2009
Citation
He, X., Bhowmick, S., and Bischof, J. C. (June 5, 2009). "Thermal Therapy in Urologic Systems: A Comparison of Arrhenius and Thermal Isoeffective Dose Models in Predicting Hyperthermic Injury." ASME. J Biomech Eng. July 2009; 131(7): 074507. https://doi.org/10.1115/1.3128671
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