Over the past decade, road safety research and impact biomechanics have strongly stimulated the development of anatomical human numerical models using the finite element (FE) approach. The good accuracy of these models, in terms of geometric definition and mechanical response, should now find new areas of application. We focus here on the use of such a model to investigate its potential when studying respiratory mechanics. The human body FE model used in this study was derived from the RADIOSS® HUMOS model. Modifications first concerned the integration and interfacing of a user-controlled respiratory muscular system including intercostal muscles, scalene muscles, the sternocleidomastoid muscle, and the diaphragm and abdominal wall muscles. Volumetric and pressure measurement procedures for the lungs and both the thoracic and abdominal chambers were also implemented. Validation of the respiratory module was assessed by comparing a simulated maximum inspiration maneuver to volunteer studies in the literature. Validation parameters included lung volume changes, rib rotations, diaphragm shape and vertical deflexion, and intra-abdominal pressure variation. The HUMOS model, initially dedicated to road safety research, could be turned into a promising, realistic 3D model of respiration with only minor modifications.

1.
Ratnovsky
,
A.
,
Elad
,
D.
, and
Halpern
,
P.
, 2008, “
Mechanics of Respiratory Muscles
,”
Respir. Physiol. Neurbiol.
1569-9048,
163
(
1–3
), pp.
82
89
.
2.
Loring
,
S. H.
, 1992, “
Action of Human Respiratory Muscles Inferred From Finite Element Analysis of Rib Cage
,”
J. Appl. Physiol.
8750-7587,
72
(
4
), pp.
1461
1465
.
3.
Behr
,
M.
,
Arnoux
,
P. J.
,
Serre
,
T.
,
Bidal
,
S.
,
Kang
,
H. S.
,
Thollon
,
L.
,
Cavallero
,
C.
,
Kayvantash
,
K.
, and
Brunet
,
C.
, 2003, “
A Human Model for Road Safety: From Geometrical Acquisition to Model Validation With RADIOSS
,”
Comput. Methods Biomech. Biomed. Eng.
1025-5842,
6
(
4
), pp.
263
273
.
4.
Behr
,
M.
,
Thollon
,
L.
,
Arnoux
,
P. J.
,
Serre
,
T.
,
Berdah
,
S. V.
,
Baque
,
P.
, and
Brunet
,
C.
, 2006, “
3D Reconstruction of the Diaphragm for Virtual Traumatology
,”
Surg. Radiol. Anat.
0930-1038,
28
(
3
), pp.
235
240
.
5.
Onders
,
R. P.
,
Aiyar
,
H.
, and
Mortimer
,
J. T.
, 2004, “
Characterization of the Human Diaphragm Muscle With Respect to the Phrenic Nerve Motor Points for Diaphragmatic Pacing
,”
Am. Surg.
0003-1348,
70
(
3
), pp.
241
247, discussion 247
.
6.
1999,
Biomechanics of the Musculo-Skeletal System
,
W.
Herzog
, ed.,
Wiley
,
New York
.
7.
Hoy
,
M. G.
,
Zajac
,
F. E.
, and
Gordon
,
M. E.
, 1990, “
A Musculoskeletal Model of the Human Lower Extremity: The Effect of Muscle, Tendon, and Moment Arm on the Moment-Angle Relationship of Musculotendon Actuators at the Hip, Knee, and Ankle
,”
J. Biomech.
0021-9290,
23
(
2
), pp.
157
169
.
8.
Delp
,
S. L.
,
Loan
,
J. P.
,
Hoy
,
M. G.
,
Zajac
,
F. E.
,
Topp
,
E. L.
, and
Rosen
,
J. M.
, 1990, “
An Interactive Graphics-Based Model of the Lower Extremity to Study Orthopaedic Surgical Procedures
,”
IEEE Trans. Biomed. Eng.
0018-9294,
37
(
8
), pp.
757
767
.
9.
Jacobs
,
R.
,
Bobbert
,
M. F.
, and
van Ingen Schenau
,
G. J.
, 1996, “
Mechanical Output From Individual Muscles During Explosive Leg Extensions: The Role of Biarticular Muscles
,”
J. Biomech.
0021-9290,
29
(
4
), pp.
513
523
.
10.
Raasch
,
C. C.
,
Zajac
,
F. E.
,
Ma
,
B.
, and
Levine
,
W. S.
, 1997, “
Muscle Coordination of Maximum-Speed Pedaling
,”
J. Biomech.
0021-9290,
30
(
6
), pp.
595
602
.
11.
Spector
,
S. A.
,
Gardiner
,
P. F.
,
Zernicke
,
R. F.
,
Roy
,
R. R.
, and
Edgerton
,
V. R.
, 1980, “
Muscle Architecture and Force-Velocity Characteristics of Cat Soleus and Medial Gastrocnemius: Implications for Motor Control
,”
J. Neurophysiol.
0022-3077,
44
(
5
), pp.
951
960
.
12.
Farkas
,
G. A.
,
Decramer
,
M.
,
Rochester
,
D. F.
, and
De Troyer
,
A.
, 1985, “
Contractile Properties of Intercostal Muscles and Their Functional Significance
,”
J. Appl. Physiol.
8750-7587,
59
(
2
), pp.
528
535
.
13.
Sharp
,
J. T.
,
Beard
,
G. A.
,
Sunga
,
M.
,
Kim
,
T. W.
,
Modh
,
A.
,
Lind
,
J.
, and
Walsh
,
J.
, 1986, “
The Rib Cage in Normal and Emphysematous Subjects: A Roentgenographic Approach
,”
J. Appl. Physiol.
8750-7587,
61
(
6
), pp.
2050
2059
.
14.
Gennisson
,
J. L.
,
Cornu
,
C.
,
Catheline
,
S.
,
Fink
,
M.
, and
Portero
,
P.
, 2005, “
Human Muscle Hardness Assessment During Incremental Isometric Contraction Using Transient Elastography
,”
J. Biomech.
0021-9290,
38
(
7
), pp.
1543
1550
.
15.
Cluzel
,
P.
,
Similowski
,
T.
,
Chartrand-Lefebvre
,
C.
,
Zelter
,
M.
,
Derenne
,
J. P.
, and
Grenier
,
P. A.
, 2000, “
Diaphragm and Chest Wall: Assessment of the Inspiratory Pump With MR Imaging-Preliminary Observations
,”
Radiology
0033-8419,
215
(
2
), pp.
574
583
.
16.
Bellemare
,
F.
,
Couture
,
J.
,
Cordeau
,
M. P.
,
Leblanc
,
P.
, and
Lafontaine
,
E.
, 2001, “
Anatomic Landmarks to Estimate the Length of The Diaphragm From Chest Radiographs: Effects of Emphysema and Lung Volume Reduction Surgery
,”
Chest
0012-3692,
120
(
2
), pp.
444
452
.
17.
Ratnovsky
,
A.
, and
Elad
,
D.
, 2005, “
Anatomical Model of the Human Trunk for Analysis of Respiratory Muscles Mechanics
,”
Respir. Physiol. Neurbiol.
1569-9048,
148
(
3
), pp.
245
262
.
18.
Cordero
,
P. J.
,
Morales
,
P.
,
Benlloch
,
E.
,
Miravet
,
L.
, and
Cebrian
,
J.
, 1999, “
Static Lung Volumes: Reference Values From a Latin Population of Spanish Descent
,”
Respiration
0025-7931,
66
(
3
), pp.
242
250
.
19.
Kenyon
,
C. M.
,
Cala
,
S. J.
,
Yan
,
S.
,
Aliverti
,
A.
,
Scano
,
G.
,
Duranti
,
R.
,
Pedotti
,
A.
, and
Macklem
,
P. T.
, 1997, “
Rib Cage Mechanics During Quiet Breathing and Exercise in Humans
,”
J. Appl. Physiol.
8750-7587,
83
(
4
), pp.
1242
1255
.
20.
Gauthier
,
A. P.
,
Verbanck
,
S.
,
Estenne
,
M.
,
Segebarth
,
C.
,
Macklem
,
P. T.
, and
Paiva
,
M.
, 1994, “
Three-Dimensional Reconstruction of the In Vivo Human Diaphragm Shape at Different Lung Volumes
,”
J. Appl. Physiol.
8750-7587,
76
(
2
), pp.
495
506
.
21.
Legrand
,
A.
,
Schneider
,
E.
,
Gevenois
,
P. A.
, and
De Troyer
,
A.
, 2003, “
Respiratory Effects of the Scalene and Sternomastoid Muscles in Humans
,”
J. Appl. Physiol.
8750-7587,
94
(
4
), pp.
1467
1472
.
22.
Bellemare
,
F.
,
Jeanneret
,
A.
, and
Couture
,
J.
, 2003, “
Sex Differences in Thoracic Dimensions and Configuration
,”
Am. J. Respir. Crit. Care Med.
1073-449X,
168
(
3
), pp.
305
312
.
23.
Wade
,
O. L.
, 1954, “
Movements of the thoracic cage and diaphragm in respiration
,”
J. Physiol.
,
124
(
2
), pp.
193
212
.
24.
Wilson
,
T. A.
,
Legrand
,
A.
,
Gevenois
,
P. A.
, and
De Troyer
,
A.
, 2001, “
Respiratory Effects of the External and Internal Intercostal Muscles in Humans
,”
J. Physiol.
,
530
(
Pt 2
), pp.
319
330
.
25.
Shirley
,
D.
,
Hodges
,
P. W.
,
Eriksson
,
A. E.
, and
Gandevia
,
S. C.
, 2003, “
Spinal Stiffness Changes Throughout the Respiratory Cycle
,”
J. Appl. Physiol.
8750-7587,
95
(
4
), pp.
1467
1475
.
26.
Hodges
,
P. W.
,
Eriksson
,
A. E.
,
Shirley
,
D.
, and
Gandevia
,
S. C.
, 2005, “
Intra-Abdominal Pressure Increases Stiffness of the Lumbar Spine
,”
J. Biomech.
0021-9290,
38
(
9
), pp.
1873
1880
.
27.
Grillner
,
S.
,
Nilsson
,
J.
, and
Thorensson
,
A.
, 1978, “
Intra Abdominal Pressure During Natural Movements in Man
,”
Acta Physiol. Scand.
0001-6772,
103
, pp.
275
283
.
You do not currently have access to this content.