Computational fluid dynamics (CFD) studies provide a valuable tool for evaluating the role of hemodynamics in vascular diseases such as cerebral aneurysms and atherosclerosis. However, such models necessarily only include isolated segments of the vasculature. In this work, we evaluate the influence of geometric approximations in vascular anatomy on hemodynamics in elastase induced saccular aneurysms in rabbits. One representative high aspect ratio (AR—height/neck width) aneurysm and one low AR aneurysm were created at the origin of the right common carotid artery in two New Zealand white rabbits. Three-dimensional (3D) reconstructions of the aneurysm and surrounding arteries were created using 3D rotational angiographic data. Five models with varying extents of neighboring vasculature were created for both the high and low AR cases. A reference model included the aneurysm sac, left common carotid artery (LCCA), aortic arch, and downstream trifurcation/quadrification. Three-dimensional, pulsatile CFD studies were performed and streamlines, wall shear stress (WSS), oscillatory shear index, and cross sectional velocity were compared between the models. The influence of the vascular domain on intra-aneurysmal hemodynamics varied between the low and high AR cases. For the high AR case, even a simple model including only the aneurysm, a small section of neighboring vasculature, and simple extensions captured the main features of the steamline and WSS distribution predicted by the reference model. However, the WSS distribution in the low AR case was more strongly influenced by the extent of vasculature. In particular, it was necessary to include the downstream quadrification and upstream LCCA to obtain good predictions of WSS. The findings in this work demonstrate the accuracy of CFD results can be compromised if insufficient neighboring vessels are included in studies of hemodynamics in elastase induced rabbit aneurysms. Consideration of aspect ratio, hemodynamic parameters of interest, and acceptable magnitude of error when selecting the vascular domain will increase reliability of the results while decreasing computational time.
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e-mail: ziz3@pitt.edu
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September 2010
Research Papers
Sensitivity of CFD Based Hemodynamic Results in Rabbit Aneurysm Models to Idealizations in Surrounding Vasculature
Zijing Zeng,
Zijing Zeng
Department of Mechanical Engineering and Materials Science,
e-mail: ziz3@pitt.edu
University of Pittsburgh
, 3700 O’Hara Street, Pittsburgh, PA 15261
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David F. Kallmes,
David F. Kallmes
Department of Radiology,
e-mail: kallmes.david@mayo.edu
Mayo Clinic College of Medicine
, 200 First Street Southwest, Rochester, MN 55905
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Michael J. Durka,
Michael J. Durka
Department of Mechanical Engineering and Materials Science,
University of Pittsburgh
, 3700 O’Hara Street, Pittsburgh, PA 15261
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Yonghong Ding,
Yonghong Ding
Department of Radiology,
Mayo Clinic College of Medicine
, 200 First Street Southwest, Rochester, MN 55905
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Debra Lewis,
Debra Lewis
Department of Radiology,
Mayo Clinic College of Medicine
, 200 First Street Southwest, Rochester, MN 55905
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Ramanathan Kadirvel,
Ramanathan Kadirvel
Department of Radiology,
Mayo Clinic College of Medicine
, 200 First Street Southwest, Rochester, MN 55905
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Anne M. Robertson
Anne M. Robertson
Mem. ASME
Department of Mechanical Engineering and Materials Science and Center for Vascular Remodeling and Regeneration (CVRR),
e-mail: rbertson@pitt.edu
University of Pittsburgh
, Pittsburgh, PA 15261
Search for other works by this author on:
Zijing Zeng
Department of Mechanical Engineering and Materials Science,
University of Pittsburgh
, 3700 O’Hara Street, Pittsburgh, PA 15261e-mail: ziz3@pitt.edu
David F. Kallmes
Department of Radiology,
Mayo Clinic College of Medicine
, 200 First Street Southwest, Rochester, MN 55905e-mail: kallmes.david@mayo.edu
Michael J. Durka
Department of Mechanical Engineering and Materials Science,
University of Pittsburgh
, 3700 O’Hara Street, Pittsburgh, PA 15261
Yonghong Ding
Department of Radiology,
Mayo Clinic College of Medicine
, 200 First Street Southwest, Rochester, MN 55905
Debra Lewis
Department of Radiology,
Mayo Clinic College of Medicine
, 200 First Street Southwest, Rochester, MN 55905
Ramanathan Kadirvel
Department of Radiology,
Mayo Clinic College of Medicine
, 200 First Street Southwest, Rochester, MN 55905
Anne M. Robertson
Mem. ASME
Department of Mechanical Engineering and Materials Science and Center for Vascular Remodeling and Regeneration (CVRR),
University of Pittsburgh
, Pittsburgh, PA 15261e-mail: rbertson@pitt.edu
J Biomech Eng. Sep 2010, 132(9): 091009 (10 pages)
Published Online: August 26, 2010
Article history
Received:
June 1, 2009
Revised:
February 16, 2010
Posted:
February 22, 2010
Published:
August 26, 2010
Online:
August 26, 2010
Citation
Zeng, Z., Kallmes, D. F., Durka, M. J., Ding, Y., Lewis, D., Kadirvel, R., and Robertson, A. M. (August 26, 2010). "Sensitivity of CFD Based Hemodynamic Results in Rabbit Aneurysm Models to Idealizations in Surrounding Vasculature." ASME. J Biomech Eng. September 2010; 132(9): 091009. https://doi.org/10.1115/1.4001311
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