In a previous work (Raghupathy and Barocas, 2010, “Generalized Anisotropic Inverse Mechanics for Soft Tissues,”J. Biomech. Eng., 132(8), pp. 081006), a generalized anisotropic inverse mechanics method applicable to soft tissues was presented and tested against simulated data. Here we demonstrate the ability of the method to identify regional differences in anisotropy from full-field displacements and boundary forces obtained from biaxial extension tests on soft tissue analogs. Tissue heterogeneity was evaluated by partitioning the domain into homogeneous subdomains. Tests on elastomer samples demonstrated the performance of the method on isotropic materials with uniform and nonuniform properties. Tests on fibroblast-remodeled collagen cruciforms indicated a strong correlation between local structural anisotropy (measured by polarized light microscopy) and the evaluated local mechanical anisotropy. The results demonstrate the potential to quantify regional anisotropic material behavior on an intact tissue sample.
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September 2011
Research Papers
Identification of Regional Mechanical Anisotropy in Soft Tissue Analogs
Colleen Witzenburg,
Colleen Witzenburg
Department of Mechanical Engineering,
University of Minnesota
, Minneapolis
, MN 55455
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Victor H. Barocas
Victor H. Barocas
Department of Biomedical Engineering,
e-mail: baroc001@umn.edu
University of Minnesota
, Minneapolis
, MN 55455
Search for other works by this author on:
Colleen Witzenburg
Department of Mechanical Engineering,
University of Minnesota
, Minneapolis
, MN 55455
Victor H. Barocas
Department of Biomedical Engineering,
University of Minnesota
, Minneapolis
, MN 55455e-mail: baroc001@umn.edu
J Biomech Eng. Sep 2011, 133(9): 091011 (7 pages)
Published Online: October 14, 2011
Article history
Received:
January 11, 2011
Revised:
September 9, 2011
Published:
October 14, 2011
Citation
Raghupathy , R., Witzenburg, C., Lake , S. P., Sander , E. A., and Barocas, V. H. (October 14, 2011). "Identification of Regional Mechanical Anisotropy in Soft Tissue Analogs." ASME. J Biomech Eng. September 2011; 133(9): 091011. https://doi.org/10.1115/1.4005170
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