Pedestrians are one of the most vulnerable road users. In 2019, the USA reported the highest number of pedestrian fatalities number in nearly three decades. To better protect pedestrians in car-to-pedestrian collisions (CPC), pedestrian biomechanics must be better investigated. The pre-impact conditions of CPCs vary significantly in terms of the characteristics of vehicles (e.g., front-end geometry, stiffness, etc.) and pedestrians (e.g., anthropometry, posture, etc.). The influence of pedestrian gait posture has not been well analyzed. The purpose of this study was to numerically investigate the changes in pedestrian kinematics and injuries across various gait postures in two different vehicle impacts. Five finite element (FE) human body models, that represent the 50th percentile male in gait cycle, were developed and used to perform CPC simulations with two generic vehicle FE models representing a low-profile vehicle and a high-profile vehicle. In the impacts with the high-profile vehicle, a sport utility vehicle, the pedestrian models usually slide above the bonnet leading edge and report shorter wrap around distances than in the impacts with a low-profile vehicle, a family car/sedan (FCR). The pedestrian postures influenced the postimpact rotation of the pedestrian and consequently, the impacted head region. Pedestrian posture also influenced the risk of injuries in the lower and upper extremities. Higher bone bending moments were observed in the stance phase posture compared to the swing phase. The findings of this study should be taken into consideration when examining pedestrian protection protocols. In addition, the results of this study can be used to improve the design of active safety systems used to protect pedestrians in collisions.