... (CTA) images, and hemorheological parameters including time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI) and relative residence time (RRT) were analyzed by computational fluid dynamics (CFD). The results showed that iliac vein stenosis could significantly increase the wall shear...

...-static simulations: Newtonian, Carreau, and Quemada on a severely calcified aortic heart valve and compared their ability to capture important hemodynamic parameters of wall shear stress (WSS) and the oscillatory shear index (OSI). Our findings indicate that when the shear rates were large enough...

... significantly altered blood flow patterns in the external iliac arteries, leading to a marked enlargement of atheroprone wall regions exposed to low and oscillatory wall shear stress (WSS), and enhanced multidirectional disturbance of WSS that may further impair endothelial function. In summary, our study...

... in the center of the vessel, while generating adjacent perivalvular recirculation zones. The recirculation zones are characterized by extended particle residence times and low wall shear stress (WSS) magnitudes in comparison to the rest of the lymphangion. A malformed unileaflet valve skewed lymph flow toward...

... is used to take into account the non-Newtonian viscoplastic fluid properties of mucus. Results show that the maximum wall shear stress greatly changes right prior to the rupture of the mucus plug. The surface tension influences mainly the late stage of the rupture process when the plug deforms greatly...

...Qianhui Li; Franziska Hegner; Christoph H. Bruecker An experimental study is reported which investigates the wall shear stress (WSS) distribution in a transparent model of the human aorta comparing an St. Jude Medical (SJM) Regent bileaflet mechanical heart valve (BMHV) with the Lapeyre-Triflo...

.... Manuscript received March 26, 2014; final manuscript received July 14, 2014; accepted manuscript posted July 22, 2014; published online August 6, 2014. Assoc. Editor: Dalin Tang. 26 03 2014 14 07 2014 22 07 2014 Coronary tortuosity (CT) would alter the local wall shear stress (WSS...

... and geometry contribute to the generation of nonphysiological wall shear stress (WSS). Such adverse hemodynamic conditions could have an effect on the onset of restenosis. Three-dimensional (3D), spatiotemporally resolved computational fluid dynamics (CFD) simulations of pulsatile flow with moving wall...

... conditions for clinical applications. stereoscopic particle image velocimetry (PIV) abdominal aortic aneurysm (AAA) thrombus blood flow vortex wall shear stress Computational fluid dynamics validation An abdominal aortic aneurysm (AAA) is a permanent focal dilation of an artery...

... magnitude and direction of wall shear stress (WSS) and endothelial phenotype expression, accurate representation of stent-induced flow patterns is critical if we are to predict sites susceptible to intimal hyperplasia. Despite the number of stents approved for clinical use, quantification on the alteration...

... is not extensively studied. In this work, we focus our investigation on the localized hemodynamic effects of dynamic changes in curvature and torsion. It is our objective to understand and reveal the mechanism by which changes in curvature and torsion contribute towards the observed wall shear stress distribution...

... hemodynamics in the physiologic model. In the smaller carotid model, deployment of the device lowers wall shear stress at sinus by 16% while accelerating flow entering the external carotid artery branch. Our FSI simulations of carotid arteries with deployed device show that the device induces localized...

.... The computational fluid dynamics simulations provided data on pressure differences, preferential flow pathways and wall shear stresses. Notably, the pressure difference resulting from the flow simulation parallel to the central vein (0–100 Pa) was clearly smaller than the difference from the radial (0–170 Pa...

...Timothy J. Gundert; Alison L. Marsden; Weiguang Yang; John F. LaDisa, Jr. Coronary stent design affects the spatial distribution of wall shear stress (WSS), which can influence the progression of endothelialization, neointimal hyperplasia, and restenosis. Previous computational fluid dynamics (CFD...

... towards controllable shear-induced erosion. biomechanics biomedical materials elastic constants permeability polymers tissue engineering wall shear stress topology optimization scaffold biofluid biodegradation As a fundamental premise of tissue engineering, scaffold is expected...

... were created for both the high and low AR cases. A reference model included the aneurysm sac, left common carotid artery (LCCA), aortic arch, and downstream trifurcation/quadrification. Three-dimensional, pulsatile CFD studies were performed and streamlines, wall shear stress (WSS), oscillatory shear...

... descriptors of atherosusceptible areas, rather than in their distribution. In particular, the more physiological, time-varying flow rate division deriving from the coupled simulation has the effect of damping wall shear stress (WSS) oscillations (differences among the coupled and the three fixed flow...

...Leonie Rouleau; Joanna Rossi; Richard L. Leask Inflammation plays a key role in the development and stability of coronary plaques. Endothelial cells alter their expression in response to wall shear stress (WSS). Straight/tubular and asymmetric stenosis models were designed to study the localized...

... values of wall shear stress have been found around the tear on the true lumen wall, perhaps increasing the likelihood of expanding the tear. Turbulence intensity in the tear region reaches a maximum of 70% at midsystolic deceleration phase. Incorporating the non-Newtonian behavior of blood into the same...

... that in the 129 strain (17.5 Pa). Time averaged wall shear stress magnitude in the aortic arches of B6 (left) and 129 (right) mice Wall shear stress profile along the inner curvature of the aortic arch of B6 and 129 mice. The dots mark the ostia of the three branches off the arch. mailto...