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Keywords: collagen
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Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2024, 146(7): 071002.
Paper No: BIO-23-1332
Published Online: March 19, 2024
...Nathan J. Witt; Alan E. Woessner; Jacob Herrmann; Kyle P. Quinn; Edward A. Sander Skin undergoes mechanical alterations due to changes in the composition and structure of the collagenous dermis with aging. Previous studies have conflicting findings, with both increased and decreased stiffness...
Includes: Supplementary data
Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2024, 146(7): 071001.
Paper No: BIO-23-1303
Published Online: March 19, 2024
...), approaches to reinforce or rebuild degenerative cartilage are of significant interest. While exogenous collagen crosslinking (CXL) treatments improve cartilage's mechanical properties and increase its resistance to enzymatic degradation, their effects on cartilage lubrication remain less clear. Here, we...
Includes: Supplementary data
Journal Articles
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. May 2023, 145(5): 054503.
Paper No: BIO-22-1243
Published Online: December 21, 2022
...Ning-Jiun Jan; Po-Yi Lee; Jacob Wallace; Michael Iasella; Alexandra Gogola; Bingrui Wang; Ian A. Sigal Stretch-induced collagen uncrimping underlies the nonlinear mechanical behavior of the sclera according to what is often called the process of recruitment. We recently reported experimental...
Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2022, 144(4): 041008.
Paper No: BIO-21-1138
Published Online: December 17, 2021
... that skin has a high Poisson's ratio, substantially decreases in volume during uniaxial tensile loading, and demonstrates collagen fiber kinematics that are not affine with local deformation. In order to better understand the mechanical basis for these properties, we constructed multiscale mechanical models...
Journal Articles
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. February 2022, 144(2): 024501.
Paper No: BIO-21-1123
Published Online: September 21, 2021
... it. We propose a mathematical model of fibrous networks, which reproduces qualitative features of collagen gel's stress–strain response and provides insight into the key features which impact the Young's modulus of similar fibrous tissues. This model analyzes the relationship of the Young's modulus...
Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2019, 141(9): 091015.
Paper No: BIO-19-1123
Published Online: August 2, 2019
...Christopher E. Korenczuk; Victor H. Barocas; William J. Richardson The scar that forms after a myocardial infarction is often characterized by a highly disordered architecture but generally exhibits some degree of collagen fiber orientation, with a resulting mechanical anisotropy. When viewed...
Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2019, 141(2): 021007.
Paper No: BIO-18-1239
Published Online: December 5, 2018
...) and had higher collagen content (16.10 ± 3.80%) than the myocardium (SM 2 = 55.14 ± 20.49 KPa, collagen content = 10.06 ± 4.15%) in the left ventricle. The results of this study improve our understanding of the contribution of trabeculae carneae to left ventricular compliance and will be useful...
Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2014, 136(2): 021028.
Paper No: BIO-13-1428
Published Online: February 5, 2014
.... Currently, the model does not consider the concentric, circumferential layers of elastin, collagen, and smooth muscle, which form the medial lamellae [ 39 ]. Unlike the current study, which considers the failure of the fibers within the lamellae, a study with radial and shear loading would involve...
Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2013, 135(2): 021026.
Paper No: BIO-12-1502
Published Online: February 7, 2013
...Mohammad F. Hadi; Victor H. Barocas While differences in collagen fiber alignment played a role in prescribing macroscale failure outcomes, the model must be expanded to consider the role of fiber-to-fiber connectivity, intrafibrillar matrix, and multiple protein networks in order to simulate...
Journal Articles
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2013, 135(2): 021018.
Paper No: BIO-12-1576
Published Online: February 7, 2013
...) is a rapidly fatal disease in which mortality is typically due to right ventricular (RV) failure. An excellent predictor of mortality in PAH is proximal pulmonary artery stiffening, which is mediated by collagen accumulation in hypoxia-induced pulmonary hypertension (HPH) in mice. We sought to investigate...
Journal Articles
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. September 2012, 134(9): 091005.
Published Online: August 27, 2012
... a multiscale mechanical model for the failure of collagenous soft tissues that incorporates spatial heterogeneity in the microstructure and links the failure of discrete collagen fibers to the material response of the tissue. The model, which is based on experimental failure data derived from different...
Journal Articles
Journal Articles
Journal Articles
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. July 2011, 133(7): 071007.
Published Online: July 18, 2011
... to model and predict the behavior under any load. Most ex vivo tests are performed within 24 h of dissection, so the tissue is still “alive.” For large elastic arteries; however, the passive mechanical behavior is attributed mostly to the very stable proteins, elastin, and collagen. If the testing...
Journal Articles
Journal Articles
Journal Articles
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. February 2010, 132(2): 021004.
Published Online: January 7, 2010
...-00030 Iaconis , F. , Steindler , R. , and Marinozzi , G. , 1987 , “ Measurements of Cross-Sectional Area of Collagen Structures (Knee Ligaments) by Means of an Optical Method ,” J. Biomech. 0021-9290 , 20 ( 10 ), pp. 1003 – 1010 . 10.1016/0021-9290(87)90330-7 Woo , S...
Journal Articles
Journal Articles
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. October 2009, 131(10): 101011.
Published Online: September 10, 2009
... with arteries under normal pulsatile pressure. Porcine carotid arteries were cultured for 3 and 7 days under normal, nonpulsatile, and hyperpulsatile pressures with the same mean pressure and flow rate using an ex vivo organ culture model. Fenestrae in the internal elastic lamina, collagen, fibronectin, and gap...
Journal Articles
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. October 2009, 131(10): 101010.
Published Online: September 4, 2009
... to be responsible for the initiation of the aneurysm growth. The aneurysm is regarded as a development of the adventitia, which is composed of several distinct layers of collagen fibers perfectly aligned in specified directions. The collagen fibers are the only load-bearing constituent in the aneurysm wall...