Cardiovascular disease (CVD), as the most prevalent human disease, incorporates a broad spectrum of cardiovascular system malfunctions/disorders. While cardiac transplantation is widely acknowledged as the optional treatment for patients suffering from end-stage heart failure (HF), due to its related drawbacks, such as the unavailability of heart donors, alternative treatments, i.e., implanting a ventricular assist device (VAD), it has been extensively utilized in recent years to recover heart function. However, this solution is thought problematic as it fails to satisfactorily provide lifelong support for patients at the end-stage of HF, nor does is solve the problem of their extensive postsurgery complications. In recent years, the huge technological advancements have enabled the manufacturing of a wide variety of reliable VAD devices, which provides a promising avenue for utilizing VAD implantation as the destination therapy (DT) in the future. Along with typical VAD systems, other innovative mechanical devices for cardiac support, as well as cell therapy and bioartificial cardiac tissue, have resulted in researchers proposing a new HF therapy. This paper aims to concisely review the current state of VAD technology, summarize recent advancements, discuss related complications, and argue for the development of the envisioned alternatives of HF therapy.
Skip Nav Destination
Article navigation
December 2017
Review Articles
Ventricular Assist Devices: Current State and Challenges
Siamak N. Doost,
Siamak N. Doost
Biomechanical and Tissue Engineering Lab,
Faculty of Science, Engineering and Technology,
Swinburne University of Technology,
1 Alfred Street,
Hawthorn VIC 3122, Australia
e-mail: Sndoost@swin.edu.au
Faculty of Science, Engineering and Technology,
Swinburne University of Technology,
1 Alfred Street,
Hawthorn VIC 3122, Australia
e-mail: Sndoost@swin.edu.au
Search for other works by this author on:
Liang Zhong,
Liang Zhong
National Heart Research Institute of Singapore,
National Heart Centre,
5 Hospital Drive,
Singapore 169609, Singapore;
Duke-NUS Medical School,
8 College Road,
Singapore 169857, Singapore
e-mail: Zhong.liang@nhcs.com.sg
National Heart Centre,
5 Hospital Drive,
Singapore 169609, Singapore;
Duke-NUS Medical School,
8 College Road,
Singapore 169857, Singapore
e-mail: Zhong.liang@nhcs.com.sg
Search for other works by this author on:
Yosry S. Morsi
Yosry S. Morsi
Biomechanical and Tissue Engineering Lab,
Faculty of Science, Engineering and Technology,
Swinburne University of Technology,
1 Alfred Street,
Hawthorn VIC 3122, Australia
e-mail: ymorsi@swin.edu.au
Faculty of Science, Engineering and Technology,
Swinburne University of Technology,
1 Alfred Street,
Hawthorn VIC 3122, Australia
e-mail: ymorsi@swin.edu.au
Search for other works by this author on:
Siamak N. Doost
Biomechanical and Tissue Engineering Lab,
Faculty of Science, Engineering and Technology,
Swinburne University of Technology,
1 Alfred Street,
Hawthorn VIC 3122, Australia
e-mail: Sndoost@swin.edu.au
Faculty of Science, Engineering and Technology,
Swinburne University of Technology,
1 Alfred Street,
Hawthorn VIC 3122, Australia
e-mail: Sndoost@swin.edu.au
Liang Zhong
National Heart Research Institute of Singapore,
National Heart Centre,
5 Hospital Drive,
Singapore 169609, Singapore;
Duke-NUS Medical School,
8 College Road,
Singapore 169857, Singapore
e-mail: Zhong.liang@nhcs.com.sg
National Heart Centre,
5 Hospital Drive,
Singapore 169609, Singapore;
Duke-NUS Medical School,
8 College Road,
Singapore 169857, Singapore
e-mail: Zhong.liang@nhcs.com.sg
Yosry S. Morsi
Biomechanical and Tissue Engineering Lab,
Faculty of Science, Engineering and Technology,
Swinburne University of Technology,
1 Alfred Street,
Hawthorn VIC 3122, Australia
e-mail: ymorsi@swin.edu.au
Faculty of Science, Engineering and Technology,
Swinburne University of Technology,
1 Alfred Street,
Hawthorn VIC 3122, Australia
e-mail: ymorsi@swin.edu.au
1Corresponding authors.
Manuscript received December 12, 2016; final manuscript received May 27, 2017; published online August 8, 2017. Assoc. Editor: Michael Eggen.
J. Med. Devices. Dec 2017, 11(4): 040801 (11 pages)
Published Online: August 8, 2017
Article history
Received:
December 12, 2016
Revised:
May 27, 2017
Citation
Doost, S. N., Zhong, L., and Morsi, Y. S. (August 8, 2017). "Ventricular Assist Devices: Current State and Challenges." ASME. J. Med. Devices. December 2017; 11(4): 040801. https://doi.org/10.1115/1.4037258
Download citation file:
Get Email Alerts
Cited By
Validation of a Repurposed pH Monitoring Capsule for Cecal Applications Using Novel Synthetic Cecal Contents
J. Med. Devices (March 2025)
Related Articles
Data Communication Pathway for Sensing Guidewire at Proximal Side: A Review
J. Med. Devices (June,2017)
The Role of Computational Modeling and Simulation in the Total Product Life Cycle of Peripheral Vascular Devices
J. Med. Devices (June,2017)
Evolution of a Non-Invasive Method for Providing Assistance to the Heart
J. Med. Devices (June,2009)
Development of a Non-Blood Contacting Cardiac Assist and Support Device: An In Vivo Proof of Concept Study
J. Med. Devices (December,2011)
Related Proceedings Papers
Related Chapters
Introduction
Design of Mechanical Bearings in Cardiac Assist Devices
Introduction
Mechanical Blood Trauma in Circulatory-Assist Devices
Occlusion Identification and Relief within Branched Structures
Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling