Assessing hemodynamics in vasculature is important for the development of cardiovascular diagnostic parameters and evaluation of medical devices. Benchtop experiments are a safe and comprehensive preclinical method for testing new diagnostic endpoints and devices within a controlled environment. Recent advances in three-dimensional (3D) printing have enhanced benchtop tests by allowing generation of patient-specific and pathophysiologic conditions. We used 3D printing, coupled with image processing and computer-aided design (CAD), to develop a patient-specific vascular test device from clinical data. The proximal pulmonary artery (PA) tree including the main, left, and right pulmonary arteries, with a stenosis within the left PA was selected as a representative anatomy for developing the vascular test device. Three test devices representing clinically relevant stenosis severities, 90%, 80%, and 70% area stenosis, were evaluated at different cardiac outputs (COs). A mock circulatory loop (MCL) generating pathophysiologic pulmonary pressure and flow was used to evaluate the hemodynamics within the devices. The dimensionless pressure drop–velocity ratio characteristic curves for the three stenosis severities were obtained. At a fixed CO, the dimensionless pressure drop increased nonlinearly with an increase in (a) the velocity ratio for a fixed stenosis severity and (b) the stenosis severity at a specific velocity ratio. The dimensionless pressure drop observed in vivo was similar (within 1%) to that measured in moderate area stenosis of 70% because both flows were viscous dominated. The hemodynamics of the 3D printed test device can be used for evaluating diagnostic endpoints and medical devices in a preclinical setting under realistic conditions.
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September 2019
Research-Article
Methodology for Hemodynamic Assessment of a Three-Dimensional Printed Patient-Specific Vascular Test Device
Gavin A. D'Souza,
Gavin A. D'Souza
Department of Mechanical and
Materials Engineering,
University of Cincinnati,
Cincinnati, OH 45221
Materials Engineering,
University of Cincinnati,
Cincinnati, OH 45221
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Michael D. Taylor,
Michael D. Taylor
The Heart Institute,
Cincinnati Children's Hospital Medical Center,
Cincinnati, OH 45229
Cincinnati Children's Hospital Medical Center,
Cincinnati, OH 45229
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Rupak K. Banerjee
Rupak K. Banerjee
Department of Mechanical and
Materials Engineering,
University of Cincinnati,
593 Rhodes Hall,
Cincinnati, OH 45221
e-mail: Rupak.Banerjee@uc.edu
Materials Engineering,
University of Cincinnati,
593 Rhodes Hall,
Cincinnati, OH 45221
e-mail: Rupak.Banerjee@uc.edu
1Corresponding author.
Search for other works by this author on:
Gavin A. D'Souza
Department of Mechanical and
Materials Engineering,
University of Cincinnati,
Cincinnati, OH 45221
Materials Engineering,
University of Cincinnati,
Cincinnati, OH 45221
Michael D. Taylor
The Heart Institute,
Cincinnati Children's Hospital Medical Center,
Cincinnati, OH 45229
Cincinnati Children's Hospital Medical Center,
Cincinnati, OH 45229
Rupak K. Banerjee
Department of Mechanical and
Materials Engineering,
University of Cincinnati,
593 Rhodes Hall,
Cincinnati, OH 45221
e-mail: Rupak.Banerjee@uc.edu
Materials Engineering,
University of Cincinnati,
593 Rhodes Hall,
Cincinnati, OH 45221
e-mail: Rupak.Banerjee@uc.edu
1Corresponding author.
Manuscript received May 10, 2019; final manuscript received June 10, 2019; published online July 15, 2019. Editor: William Durfee.
J. Med. Devices. Sep 2019, 13(3): 031011 (8 pages)
Published Online: July 15, 2019
Article history
Received:
May 10, 2019
Revised:
June 10, 2019
Citation
D'Souza, G. A., Taylor, M. D., and Banerjee, R. K. (July 15, 2019). "Methodology for Hemodynamic Assessment of a Three-Dimensional Printed Patient-Specific Vascular Test Device." ASME. J. Med. Devices. September 2019; 13(3): 031011. https://doi.org/10.1115/1.4043992
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