Structures that direct neurite extension are important for regeneration following spinal cord injury and peripheral nerve injury. Within the spinal cord, neurons encounter a glial scar environment that impedes regeneration. In the peripheral nervous system, endogenous regeneration cannot occur across nerve gaps greater than . Current repair strategies use guidance conduits to channel axonal growth towards distal targets. While showing promise, conduit walls do not provide a suitable environment for neuronal attachment or extension, and axonal growth within conduits remains tortuous. Hence, there is a need for development of three-dimensional (3D) structures that use contact guidance—rather than confinement—as a means of guided regeneration. Our laboratory has developed aligned, electrospun fiber matrices that have been shown to direct neurite extension in vitro. In addition, a gradient of the glycoprotein laminin-1 has been adsorbed onto aligned microfiber matrices to stimulate directional growth. These matrices were then manipulated into 3D conduit structures. Novel polymeric conduits that utilize contact guidance and contain gradients of molecules that stimulate directional growth have the potential to foster fast, directed regeneration into and through conduit structures.
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Development of Polymeric Nerve Guidance Conduits That Contain Anisotropic Cues Including Aligned Microfibers and Gradients of Adsorbed Laminin-1
Jared M. Cregg,
Jared M. Cregg
Michigan Technological University
, Houghton, MI USA
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Han Bing Wang,
Han Bing Wang
Michigan Technological University
, Houghton, MI USA
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Michael E. Mullins, Ph.D.,
Michael E. Mullins, Ph.D.
Michigan Technological University
, Houghton, MI USA
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Ryan J. Gilbert, Ph.D.
Ryan J. Gilbert, Ph.D.
Michigan Technological University
, Houghton, MI USA
Search for other works by this author on:
Jared M. Cregg
Michigan Technological University
, Houghton, MI USA
Han Bing Wang
Michigan Technological University
, Houghton, MI USA
Michael E. Mullins, Ph.D.
Michigan Technological University
, Houghton, MI USA
Ryan J. Gilbert, Ph.D.
Michigan Technological University
, Houghton, MI USAJ. Med. Devices. Jun 2008, 2(2): 027524 (1 pages)
Published Online: June 12, 2008
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Published:
June 12, 2008
Citation
Cregg, J. M., Wang, H. B., Mullins, M. E., and Gilbert, R. J. (June 12, 2008). "Development of Polymeric Nerve Guidance Conduits That Contain Anisotropic Cues Including Aligned Microfibers and Gradients of Adsorbed Laminin-1." ASME. J. Med. Devices. June 2008; 2(2): 027524. https://doi.org/10.1115/1.2934348
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