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Proceedings Papers

Modeling the Dynamic Composition of Engineered Cartilage

Christopher G. Wilson, Sean S. Kohles, Lawrence J. Bonassar

Proc. ASME. IMECE2001, Advances in Bioengineering, 15-16, November 11–16, 2001

Paper No: IMECE2001/BED-23007

DOI: https://doi.org/10.1115/IMECE2001/BED-23007

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Topics: Cartilage, Modeling, Biological tissues, Polymers

Proceedings Papers

Analysis of Bending Behavior of Native Auricular and Costal Cartilage and Tissue Engineered Constructs

Rani Roy, Sean S. Kohles, Victor Zaporojan, Lawrence Bonassar

Proc. ASME. IMECE2001, Advances in Bioengineering, 19-20, November 11–16, 2001

Paper No: IMECE2001/BED-23009

DOI: https://doi.org/10.1115/IMECE2001/BED-23009

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Topics: Biological tissues, Cartilage, Deflection, Deformation, Elastic moduli, Elasticity, Mechanical properties, Soft tissues

Journal Articles

Three-Dimensional Culture of Cells and Matrix Biomolecules for Engineered Tissue Development and Biokinetics Model Validation

Shelley S. Mason, Sean S. Kohles, Randy D. Zelick, Shelley R. Winn, Asit K. Saha

J. Nanotechnol. Eng. Med. May 2011, 2(2): 025001.

DOI: https://doi.org/10.1115/1.4003878

Published Online: May 19, 2011

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Topics: Biological tissues, Biomaterials, Bioreactors, Cartilage, Chondrocytes

Journal Articles

Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov’s Theorem to Biomolecule Homeostasis

Asit K. Saha, Yu Liang, Sean S. Kohles

J. Nanotechnol. Eng. Med. May 2011, 2(2): 021004.

DOI: https://doi.org/10.1115/1.4003876

Published Online: May 13, 2011

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Topics: Biological tissues, Cartilage, Chondrocytes, Diseases, Musculoskeletal system, Stress, Theorems (Mathematics), Simulation, Dynamics (Mechanics), Differential equations

Journal Articles

Volumetric Stress-Strain Analysis of Optohydrodynamically Suspended Biological Cells

Sean S. Kohles, Yu Liang, Asit K. Saha

J Biomech Eng. January 2011, 133(1): 011004.

DOI: https://doi.org/10.1115/1.4002939

Published Online: December 22, 2010

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Topics: Biological cells, Biomechanics, Stress, Microfluidics, Flow (Dynamics)

Proceedings Papers

Modeling Nanomechanical Strains in Healthy and Diseased Single-Cells Due to Applied Fluidic Stresses

Zachary D. Wilson, Sean S. Kohles

Proc. ASME. NEMB2010, ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology, 325-327, February 7–10, 2010

Paper No: NEMB2010-13010

DOI: https://doi.org/10.1115/NEMB2010-13010

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Topics: Modeling, Stress, Flow (Dynamics), Microfluidics, Resolution (Optics), Biology, Biomechanics, Cellular mechanics, Chondrocytes, Diseases

Journal Articles

A Multivariate Logistical Model for Identifying the Compressive Sensitivity of Single Rat Tactile Receptors as Nanobiosensors

Sean S. Kohles, Sam Bradshaw, Shelley S. Mason, Fred J. Looft

J. Nanotechnol. Eng. Med. February 2011, 2(1): 011002.

DOI: https://doi.org/10.1115/1.4002750

Published Online: December 13, 2010

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Topics: Biosensors, Modeling, Skin, Stress, Nanoscale phenomena, Compressive stress

Journal Articles

Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis

Asit K. Saha, Sean S. Kohles

J. Nanotechnol. Eng. Med. November 2010, 1(4): 041001.

DOI: https://doi.org/10.1115/1.4002461

Published Online: October 21, 2010

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Topics: Biological tissues, Biomechanics, Cartilage, Chondrocytes, Steady state, Stress, Dynamics (Mechanics), Nanoscale phenomena, Modeling

Journal Articles

A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Static Nanomechanical Stimulation in a Cartilage Biokinetics Model

Asit K. Saha, Sean S. Kohles

J. Nanotechnol. Eng. Med. August 2010, 1(3): 031005.

DOI: https://doi.org/10.1115/1.4001934

Published Online: August 10, 2010

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Topics: Cartilage, Microfluidics, Nanoscale phenomena, Stress, Steady state, Biology, Simulation, Biological tissues, Dynamics (Mechanics)

Journal Articles

Two-Dimensional Modeling of Nanomechanical Strains in Healthy and Diseased Single-Cells During Microfluidic Stress Applications

Zachary D. Wilson, Sean S. Kohles

J. Nanotechnol. Eng. Med. May 2010, 1(2): 021005.

DOI: https://doi.org/10.1115/1.4001309

Published Online: May 5, 2010

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Topics: Flow (Dynamics), Microfluidics, Stress

Journal Articles

Mechanical Stress Analysis of Microfluidic Environments Designed for Isolated Biological Cell Investigations

Sean S. Kohles, Nathalie Nève, Jeremiah D. Zimmerman, Derek C. Tretheway

J Biomech Eng. December 2009, 131(12): 121006.

DOI: https://doi.org/10.1115/1.4000121

Published Online: November 10, 2009

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Topics: Flow (Dynamics), Fluids, Stress, Gravity (Force), Microfluidics, Shear (Mechanics), Microchannel flow

Proceedings Papers

Exploring Microscale Phenomena With the µPIVOT (µPIV and Optical Tweezers)

Derek C. Tretheway, Nathalie Ne`ve, Sean S. Kohles

Proc. ASME. IMECE2008, Volume 13: Nano-Manufacturing Technology; and Micro and Nano Systems, Parts A and B, 971-973, October 31–November 6, 2008

Paper No: IMECE2008-67901

DOI: https://doi.org/10.1115/IMECE2008-67901

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Topics: Fluid-dynamic forces, Fluids, Microscale devices, Non-Newtonian fluids, Particulate matter, Rheology, Theoretical analysis

Proceedings Papers

An Integrated Micron-Resolution Particle Image Velocimeter/Optical Tweezers (μPIVOT) for Microenvironment Investigations

James K. Lingwood, Nathalie Ne`ve, Sean S. Kohles, Derek C. Tretheway

Proc. ASME. IMECE2007, Volume 11: Micro and Nano Systems, Parts A and B, 835-837, November 11–15, 2007

Paper No: IMECE2007-41996

DOI: https://doi.org/10.1115/IMECE2007-41996

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Topics: Particulate matter, Resolution (Optics), Velocimeters, Microscale devices, Cellular mechanics, Flow (Dynamics), Hydrodynamics, Instrumentation, Lasers, Non-Newtonian fluids

Proceedings Papers

Microfluidics Supporting an Optical Instrument for Multimodal Single Cell Biomechanics

Nathalie Ne`ve, James K. Lingwood, Shelley R. Winn, Derek C. Tretheway, Sean S. Kohles

Proc. ASME. IMECE2007, Volume 11: Micro and Nano Systems, Parts A and B, 839-841, November 11–15, 2007

Paper No: IMECE2007-42004

DOI: https://doi.org/10.1115/IMECE2007-42004

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Topics: Cellular mechanics, Microfluidics, Optical instruments, Stress, Biomechanics, Compression, Deformation, Fluids, Hydrostatic pressure, Particulate matter

Journal Articles

A Mechanical Composite Spheres Analysis of Engineered Cartilage Dynamics

Sean S. Kohles, Christopher G. Wilson, Lawrence J. Bonassar

J Biomech Eng. August 2007, 129(4): 473–480.

DOI: https://doi.org/10.1115/1.2746366

Published Online: November 22, 2006

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Topics: Cartilage, Composite materials, Biological tissues, Biomechanics, Elasticity, Chondrocytes, Polymers

Journal Articles

A First-Order Mechanical Device to Model Traumatized Craniovascular Biodynamics

Sean S. Kohles, Ryan W. Mangan, Edward Stan, James McNames

J. Med. Devices. March 2007, 1(1): 89–95.

DOI: https://doi.org/10.1115/1.2355689

Published Online: July 30, 2006

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Topics: Biological tissues, Blood, Brain, Design, Flow (Dynamics), Physiology, Pressure, Traumatic brain injury, Wounds, Cerebrospinal fluid

Journal Articles

Linear Poroelastic Cancellous Bone Anisotropy: Trabecular Solid Elastic and Fluid Transport Properties

Sean S. Kohles, ASME Member, Julie B. Roberts

J Biomech Eng. October 2002, 124(5): 521–526.

DOI: https://doi.org/10.1115/1.1503374

Published Online: September 30, 2002

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Topics: Anisotropy, Biological tissues, Bone, Elasticity, Fluids, Porosity, Permeability, Elastic moduli, Biomechanics

Journal Articles

Thermographic Stress Analysis in Cortical Bone

Ray Vanderby, Jr., Sean S. Kohles

J Biomech Eng. November 1991, 113(4): 418–422.

DOI: https://doi.org/10.1115/1.2895421

Published Online: November 1, 1991

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Topics: Bone, Stress analysis (Engineering), Heat flux, Temperature, Stress, Biomechanics, Density, Strain gages, Thermoelasticity

Journal citation

NARROW

Modeling the Dynamic Composition of Engineered Cartilage

Analysis of Bending Behavior of Native Auricular and Costal Cartilage and Tissue Engineered Constructs

Three-Dimensional Culture of Cells and Matrix Biomolecules for Engineered Tissue Development and Biokinetics Model Validation

Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov’s Theorem to Biomolecule Homeostasis

Volumetric Stress-Strain Analysis of Optohydrodynamically Suspended Biological Cells

Modeling Nanomechanical Strains in Healthy and Diseased Single-Cells Due to Applied Fluidic Stresses

A Multivariate Logistical Model for Identifying the Compressive Sensitivity of Single Rat Tactile Receptors as Nanobiosensors

Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis

A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Static Nanomechanical Stimulation in a Cartilage Biokinetics Model

Two-Dimensional Modeling of Nanomechanical Strains in Healthy and Diseased Single-Cells During Microfluidic Stress Applications

Mechanical Stress Analysis of Microfluidic Environments Designed for Isolated Biological Cell Investigations

Exploring Microscale Phenomena With the µPIVOT (µPIV and Optical Tweezers)

An Integrated Micron-Resolution Particle Image Velocimeter/Optical Tweezers (μPIVOT) for Microenvironment Investigations

Microfluidics Supporting an Optical Instrument for Multimodal Single Cell Biomechanics

A Mechanical Composite Spheres Analysis of Engineered Cartilage Dynamics

A First-Order Mechanical Device to Model Traumatized Craniovascular Biodynamics

Linear Poroelastic Cancellous Bone Anisotropy: Trabecular Solid Elastic and Fluid Transport Properties

Thermographic Stress Analysis in Cortical Bone

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